The Food and Drug Administration announced in a post Tuesday night it has issued an emergency use authorization for the first COVID-19 test for self-testing at home — and it returns rapid results.

Why it matters: Coronavirus cases, hospitalizations and deaths from the virus are accelerating across the U.S. This rapid home test could help reduce testing delays and quickly determine whether people need isolate due to a coronavirus infection.

President Trump announced on Twitter Tuesday night that Christopher Krebs, the head of the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency, had been fired effective immediately.

Why it matters: Krebs, who is responsible for securing voting technology, has drawn bipartisan praise for his handling of the election and debunking of misinformation. Reuters recently reported he expected to be fired after he pushed back against false claims that Democrats "rigged" the election, a claim that Trump has heavily promoted.

The Wayne County Board of Canvassers struck a last-minute compromise on Tuesday night to certify local election results, backpedaling on a tactic that could have delayed official approval statewide.

Why it matters: The board's Republican members voted earlier Tuesday to block certification, in a move that President Trump celebrated on Twitter. The reversal is a blow to Trump and his GOP allies who have sought to delay or block President-elect Biden's victories in a number of jurisdictions, mostly through failed legal action.

Sen. Chuck Grassley (R-Iowa) has tested positive for the coronavirus, he tweeted Tuesday.

Why it matters: Grassley is the second oldest member of the Senate at 87 years old, meaning he is at high risk for a severe infection, according to the CDC. The Iowa senator is the third in the line of succession to the presidency as president pro tempore of the Senate.

1. Health: Cases are peaking now in most of the country — Health care workers at a breaking point — Axios-Ipsos poll: The coronavirus wakeup call.
2. Economy: Vaccine hopes are powering Wall Street.
3. Politics: Biden's coronavirus challenge: Reaching Trump voters.
4. Social media: Cases are spiking, but our attention isn’t.
5. 🎧 Podcast: Moderna's chief medical officer on its blockbuster vaccine news.

Systemic racism is leading to a turnover problem in corporate America: Companies have a hard time holding on to Black employees.

Why it matters: Beyond affecting individual professionals and teams, a corporate culture that causes attrition can spread rot through entire companies.

President Trump's controversial Fed pick Judy Shelton appears to be blocked from joining the central bank's board, for now — a dramatic turn of events, marred by two senators who were expected to support her, but were in quarantine for COVID-related concerns.

Why it matters: Some Republicans broke ranks and opposed Shelton, who in the past has endorsed fringe economic policies and reversed her beliefs to be more in line with those of Trump. Vice President-elect Kamala Harris cast a crucial vote against Shelton on Tuesday, with the final tally coming out to 50-47.

Acting Secretary of Defense Christopher Miller announced on Tuesday that the U.S. would draw down its troop levels in both Afghanistan and Iraq to 2,500 by Jan. 15, 2021.

Why it matters: The U.S. currently has roughly 4,500 troops in Afghanistan, so this will be a significant reduction even as it falls short of President Trump's promise to end America's military presence there altogether.

President-elect Biden spoke on the phone today with Israeli Prime Minister Benjamin Netanyahu and Israeli President Reuven Rivlin as part of series of congratulatory phone calls with leaders around the world.

The big picture: The order in which these calls are returned by an incoming president is closely watched. Biden called Netanyahu and Rivlin after speaking with the leaders of nine other U.S. allies over the past few days.

The U.S. State Department's Office of Policy Planning is set to release a blueprint for America’s response to China’s rise as an authoritarian superpower, Axios has learned.

Why it matters: The lengthy document calls for strong alliances and rejuvenation of constitutional democracy. Axios obtained a copy.

President-elect Joe Biden is bringing two longtime confidants — Steve Ricchetti and Mike Donilon — into the West Wing along with newer faces as he fills out out his senior White House staff.

Driving the news: Biden named Ron Klain as his chief of staff last week, and on Tuesday announced other members of his senior team.

Private equity dominated Election Day. Not in terms of the winning candidates, but in terms of the election process itself.

Between the lines: The most-utilized election system and software companies are owned by U.S. private equity firms. Dominion Voting Systems is the best-known of these vendors, as it's become the subject of evidence-free conspiracy theories.

In filing for a $1 billion stock offering Monday, Airbnb is betting investors will look past the company's coronavirus-induced struggles and see a brighter future.

Between the lines: Airbnb faces pressure to go public despite the pandemic so it can deliver liquidity both to investors and to early employees, whose options will eventually expire.

A new coalition is launching — with Tesla, Uber, power giants like Southern Company, and others — that will push for electric models to account for 100% of new U.S. vehicle sales by 2030.

Why it matters: While electric vehicles are a growing technology, new corporate lobbying efforts — especially by powerful companies — could help spur faster growth in what remains a largely niche market.

Amazon launched Amazon Pharmacy on Tuesday, which will allow U.S. customers to order prescription medications without leaving their homes.

Why it matters via Axios' Dan Primack: With the pharmaceutical business going digital, this could create a major challenge for companies like CVS and Walgreens, whose stocks stumbled this morning after Amazon's announcement.

The NCAA announced Monday that it will consolidate March Madness to a single city in 2021, likely Indianapolis.

Why it matters: The NCAA lost $375 million when it canceled March Madness this past spring, and with COVID-19 surging heading into the winter, utilizing a bubble could be the only way to successfully complete the event.

Here’s one thing Wall Street investors can say that other Americans can’t: Things are looking really good.

Why it matters: The backdrop is the worst rate of coronavirus infections since the pandemic began. But that’s no match for a prospective vaccine down the line, which adds to already favorable conditions for investors.

A new class of conservative outlets and networks is racing to capture the attention of disgruntled Trump voters, who feel abandoned by traditional news companies and censored by social media.

Why it matters: Fox News, for years, has been criticized for polarizing coverage. Now, there’s a race unfolding among several conservative outlets who don’t think Fox is pro-Trump enough.

The day he enters the White House, President-elect Joe Biden will inherit a host of China-related challenges that require immediate action, from restoring diplomatic backchannels with China to figuring out what to do about lingering tariffs.

The big picture: Biden must find a way to put the U.S.-China relationship on a more sustainable path while preserving U.S. national security interests and blocking China's efforts to weaken international norms.

While some parts of the country endured high rates of coronavirus infection in the spring and summer, most of the country is experiencing the worst of it right now.

By the numbers: Most American counties — 58% of them — have seen the peak of their coronavirus infections this month, and 76% of counties have peaked at some point in the fall.

Ahead of Thanksgiving travel, new coronavirus cases in the U.S. have never been higher, and online interest in the pandemic has never been lower, according to data from NewsWhip provided to Axios.

Why it matters: The novelty of the virus has long worn off with half a year passed since our lives were upended. But the health risks haven't gone anywhere.

The nationwide surge in coronavirus infections is prompting some Americans to take high-risk behaviors more seriously, according to the latest installment of the Axios-Ipsos Coronavirus Index.

Why it matters: Our latest survey shows that more people — and more Republicans, in particular — are attuned to the risks of indoor activities. That’s a positive sign, if the U.S. has any hope of getting this latest outbreak under control.

Hurricane Iota made landfall in Nicaragua late Monday as an "extremely dangerous" Category 4 storm, packing maximum sustained winds of 155 mph, per the National Hurricane Center.

Why it matters: The storm is the most powerful of the 2020 Atlantic hurricane season, with "life-threatening storm surge, catastrophic winds, flash flooding, and landslides expected across portions of Central America," the NHC said.

The number of people hospitalized with COVID-19 in the U.S. reached a new record high of 73,014 on Monday, per the COVID Tracking Project.

Driving the news: Governors in several states announced new restrictions to combat the wave of rapid COVID-19 spread, with fears that the numbers will continue to accelerate as people gather for the Thanksgiving holiday.

Nearly 90,000 sexual abuse claims were submitted against the Boy Scouts of America (BSA) ahead of a Monday deadline in the organization's bankruptcy case.

Why it matters: The number of sex abuse cases is still likely underreported. Paul Mones, a lawyer who has been working on Boy Scouts cases for nearly two decades, told Axios he expects the total number of reported cases to be "closer" to 100,000. He's calling for a congressional inquiry into the scandal.

The vaccine breakthroughs from Pfizer and Moderna are incredible news, for a small sliver of the world.

The big picture: Wealthy countries like the U.S. have secured their access to those vaccines and others and are increasingly confident they'll begin mass vaccination this spring. But according to research from Duke University's Global Health Institute, there likely won't be enough doses to cover the entire global population until 2024.