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"Oprah Winfrey Show" turns 40: How it transformed Chicago

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Blue Harpo Studios sign with red neon 'HARPO STUDIOS' above a digital marquee reading 'THE OPRAH WINFREY SHOW' and a blue panel below showing 'OPRAH WINFREY SHOW'.

"The Oprah Winfrey Show" at Harpo Studios in the West Loop in 2003. Photo: Walter McBride/Corbis via Getty Images

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