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Lauryn Morley, a lower school substitute teacher for the Washington Waldorf School in Bethesda, Maryland, works from her home in Arlington, Virginia. Photo: Olivier Douliery/AFP via Getty Images

The number of novel coronavirus cases in the U.S. has grown from one on Jan. 21 to more than 312,000 by early Sunday, per Johns Hopkins.

The big picture: Roughly three-quarters of the American population is on lockdown, with social distancing measures and other orders in place across the country. Here's how Americans are coping with the massive upheaval the outbreak has brought, in photos.

Miami residents applaud from their balconies in solidarity for health care workers, first responders, supermarket employees and all the professions helping to fight COVID-19. Photo: Chandan Khanna/AFP via Getty Images
A sanitation station in Philadelphia. Photo: Cory Clark/NurPhoto via Getty Images
The Samaritan's Purse emergency field hospital for coronavirus patients in New York City's Central Park. Photo: Bryan R. Smith/AFP via Getty Images
Cellist Jodi Beder performs a daily concert on her front porch in Mount Rainier, Maryland, to help people passing by and her neighbors cope with the outbreak. Photo: Andrew Caballero-Reynolds/AFP via Getty Images
Martha's Table volunteer Poet Taylor helps distribute hundreds of free hot meals to people in need in Washington, D.C. Photo: Chip Somodevilla/Getty Images
O'Hare International Airport in Chicago, which typically serves 8.2 million passengers a month, has closed two of its seven runways as the pandemic has significantly reduced air travel. Photo: Scott Olson/Getty Images
People keep to social distancing guidelines in Portland, Oregon. Photo: Alex Milan Tracy/Anadolu Agency via Getty Images
Signs are posted throughout Long Beach, California, reminding residents of what areas are closed. Photo: Brittany Murray/MediaNews Group/Long Beach Press-Telegram via Getty Images
A police officer outside the closed Alamo in San Antonio, Texas. Photo: Mark Felix/AFP via Getty Images
U.S. Customs officers at the U.S.-Canada border in Lansdowne, Ontario. Photo: Lars Hagberg/AFP via Getty Images
The L.L. Bean plant in Brunswick, Maine, has begun producing safety masks during the COVID-19 epidemic. Photo: Blake Nissen for The Boston Globe via Getty Images
A police officer at the entrance to a coronavirus testing center in Hansen Dam Park, Pacoima, California. Photo: Frederic J. Brown/AFP via Getty Images
People around the world have been placing stuffed bears in their windows to keep kids entertained during the outbreak — including this house in Boston's Hyde Park. Photo: Lane Turner/The Boston Globe via Getty Images

Go deeper: What a coronavirus exit ramp looks like

Go deeper

Oct 27, 2020 - World

Putin mandates face masks as Russia combats second COVID-19 wave

Russian President Vladimir Putin. Photo: Alexei Druzhinin/Sputnik/AFP via Getty Images

Russian President Vladimir Putin on Tuesday instituted a nationwide mask mandate, as the nation tries to combat a second spike of COVID-19 cases, according to an order published by Rospotrebnadzor, the federal health watchdog agency.

By the numbers: Russia currently has the fourth-most coronavirus cases in the world, with 1,537,142, according to Johns Hopkins data, behind the U.S., India and Brazil. Russia has reported 26,092 deaths to date.

Updated 22 hours ago - Politics & Policy

Coronavirus dashboard

Illustration: Aïda Amer/Axios

  1. Vaccines: U.S. to mandate vaccines for anyone who crosses borders starting in January — Shots lagged data by months — The next big bottleneck in the global vaccination effort.
  2. Health: The Thanksgiving bouncers — Axios-Ipsos poll: Thanksgiving roulette — Experts criticize CDC's language on vaccine boosters — America's Thanksgiving gamble.
  3. Politics: Biden administration asks appeals court to reinstate vaccine mandate — Michigan recommends face masks for all residents amid surge.
  4. Education: A COVID strategy backfires at schools — Schools across the U.S. offer vaccine drivesBenefits of in-person school outweigh risks, study finds.
  5. World: EU drug regulator recommends Pfizer COVID vaccine for kids — Italy announces new COVID restrictions for unvaccinated people — European health agency urges expanding booster shot access.
  6. Variant tracker: Where different strains are spreading.
24 mins ago - Health

First cases of COVID-19 Omicron variant discovered in United Kingdom

People wearing masks walk in London on Nov. 25. Photo: Li Ying/Xinhua via Getty Images

Two cases of the new COVID-19 Omicron variant were detected in the United Kingdom overnight, the U.K. Health Security Agency announced Saturday.

Why it matters: The discovery comes as the world scrambles to respond to concerns over the new variant, discovered in South Africa earlier this week.