Lauryn Morley, a lower school substitute teacher for the Washington Waldorf School in Bethesda, Maryland, works from her home in Arlington, Virginia. Photo: Olivier Douliery/AFP via Getty Images

The number of novel coronavirus cases in the U.S. has grown from one on Jan. 21 to more than 312,000 by early Sunday, per Johns Hopkins.

The big picture: Roughly three-quarters of the American population is on lockdown, with social distancing measures and other orders in place across the country. Here's how Americans are coping with the massive upheaval the outbreak has brought, in photos.

Miami residents applaud from their balconies in solidarity for health care workers, first responders, supermarket employees and all the professions helping to fight COVID-19. Photo: Chandan Khanna/AFP via Getty Images
A sanitation station in Philadelphia. Photo: Cory Clark/NurPhoto via Getty Images
The Samaritan's Purse emergency field hospital for coronavirus patients in New York City's Central Park. Photo: Bryan R. Smith/AFP via Getty Images
Cellist Jodi Beder performs a daily concert on her front porch in Mount Rainier, Maryland, to help people passing by and her neighbors cope with the outbreak. Photo: Andrew Caballero-Reynolds/AFP via Getty Images
Martha's Table volunteer Poet Taylor helps distribute hundreds of free hot meals to people in need in Washington, D.C. Photo: Chip Somodevilla/Getty Images
O'Hare International Airport in Chicago, which typically serves 8.2 million passengers a month, has closed two of its seven runways as the pandemic has significantly reduced air travel. Photo: Scott Olson/Getty Images
People keep to social distancing guidelines in Portland, Oregon. Photo: Alex Milan Tracy/Anadolu Agency via Getty Images
Signs are posted throughout Long Beach, California, reminding residents of what areas are closed. Photo: Brittany Murray/MediaNews Group/Long Beach Press-Telegram via Getty Images
A police officer outside the closed Alamo in San Antonio, Texas. Photo: Mark Felix/AFP via Getty Images
U.S. Customs officers at the U.S.-Canada border in Lansdowne, Ontario. Photo: Lars Hagberg/AFP via Getty Images
The L.L. Bean plant in Brunswick, Maine, has begun producing safety masks during the COVID-19 epidemic. Photo: Blake Nissen for The Boston Globe via Getty Images
A police officer at the entrance to a coronavirus testing center in Hansen Dam Park, Pacoima, California. Photo: Frederic J. Brown/AFP via Getty Images
People around the world have been placing stuffed bears in their windows to keep kids entertained during the outbreak — including this house in Boston's Hyde Park. Photo: Lane Turner/The Boston Globe via Getty Images

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Updated 15 hours ago - Health

World coronavirus updates

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Data: The Center for Systems Science and Engineering at Johns Hopkins; Map: Axios Visuals

Prime Minister Jacinda Ardern announced all domestic pandemic restrictions will be lifted in New Zealand from midnight Monday except in Auckland, where they'll be eased late Wednesday.

The big picture: Ardern delayed the country's election until Oct. 17 as authorities work to stamp out a coronavirus cluster in Auckland, after the re-emergence of COVID-19. There have been single-digit or zero domestic cases in NZ's most populous city since the government reintroduced restrictions.

Updated Sep 20, 2020 - Health

7 states set single-day coronavirus case records last week

Data: Compiled by Axios; Map: Danielle Alberti/Axios

Seven states set new highs last week for coronavirus infections recorded in a single day, according to the COVID Tracking Project and state health departments. Wisconsin and Nebraska surpassed records set the previous week.

Why it matters: Problem spots are sticking in the Midwest, although the U.S. is moving in the right direction overall after massive infection spikes this summer.

24 hours ago - Health

Ex-FDA chief: Career scientists won't be "easily cowed" by political vaccine pressure

The career scientists involved in the approval process will not be swayed by politics, former FDA commissioner Scott Gottlieb said on CBS' "Face the Nation" Sunday.

Why it matters: Gottlieb's comments come amid fears that the Trump administration has politicized the coronavirus response and is seeking rapid approval and distribution of a vaccine.