Arkansas ead coach John Calipari looks on against the High Point Panthers during the first half in the second round of the NCAA Men's Basketball Tournament March 21 in Portland, Ore.
Arizona defeated Arkansas on Thursday night, 109-88, in the NCAA Sweet 16 played in San Jose, California.
The loss delivers a disappointing end to a hot postseason run.
What's next: The No. 1-seeded Arizona Wildcats advance to face No. 2-seeded Purdue Boilermakers in the Elite Eight on Saturday.
The big picture: Arkansas has reached the Elite Eight 11 times and the Final Four six times.
Flashback: Last year, the first for head coach John Calipari, the Razorbacks progressed to the NCAA Sweet 16, beating Kansas and 5th-ranked St. John's, before falling to 9th-ranked Texas Tech in overtime.