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A man records the 2-mile Walk to End Alzheimer's finish in Huntington Beach on Saturday, October 6, 2018. Photo: Mindy Schauer/Digital First Media/Orange County Register via Getty Images

Scientists are seeking early diagnostics for Alzheimer's that could predict who is likely to develop the disease before noticeable symptoms materialize. In recent months, a large study was published showing that certain PET scans can lead to more accurate diagnoses, while other researchers are looking for disease biomarkers that may be evident in the eye, spinal fluid or the blood.

Why it matters: Alzheimer's, which is expected to affect 14 million Americans by 2060, starts decades before outward signs are indicated. While high-profile drug treatment trial failures, which were aimed at halting the degenerative disease, have occurred recently, scientists believe there are steps people can take that may help delay memory loss or alleviate other symptoms — and catching Alzheimer's early may be especially beneficial.

Background:

  • A major focus of research is on possible drug treatments targeting the clumps of protein (amyloid plaques) and tangled bundles of fibers (tau proteins) in the brain, but with recent trial failures, debate has sharpened over whether treatment research needs to look elsewhere.
  • Even if some researchers believe plaques and tau proteins may not play a causative role, they are considered hallmarks of the disease that diagnostics work is built around.

What's new: Howard Fillit, founding executive director and chief science officer of the Alzheimer’s Drug Discovery Foundation, tells Axios:

  • "There's a lot of excitement in the field right now ... despite the [recent failure in some] clinical trials. There's over 100 studies being conducted now, with roughly half in amyloid and tau research."
  • A large study of 11,049 people with mild cognitive impairment (MCI) or dementia published in JAMA Tuesday shows PET scans identifying amyloid plaques changed clinical care, such as drugs and counseling, by roughly two-thirds.
  • Fillit says that if Medicare would allow the tool, he believes people would not only get the proper diagnosis and symptom alleviation they need, but clinical trials would improve by having a larger and definite pool of Alzheimer's patients to study.

Other exciting developments in the works, Fillit says, are tests of early diagnostics in the eyes, blood and spinal fluid that look for amyloids and tau, plus inflammatory and neurodegeneration markers. He expects a blood test in a couple years and says "this is a really exciting time for biomarkers in this space."

Biomarkers are something — such as amyloids — that can be measured and indicate the possible presence of a disease. Fillit points to...

Meanwhile, Jeff and MacKenzie Bezos joined the Diagnostics Accelerator formed over the summer to develop novel biomarkers for the early detection of Alzheimer's, bringing the total funding for new grants over the next 3 years to $50 million, ADDF announced Tuesday.

The bottom line: Billions are being spent by the U.S. government and biotech companies to understand the cause and to pin down better diagnostics and treatments. "Alzheimer's will look like cancer [research] soon," Fillit says. "We will have precision medicine."

Go deeper:

Go deeper

1 hour ago - Science

The "war on nature"

A resident stands on his roof as the Blue Ridge Fire burned back in October in Chino Hills, Calif. Photo: Jae C. Hong/AP

Apocalyptic weather is the new normal because humans are "waging war on nature," the UN declared on Wednesday.

What they're saying: "The state of the planet is broken," said UN Secretary-General António Guterres, reports AP. “This is suicidal.”

Updated 3 hours ago - Politics & Policy

Coronavirus dashboard

Illustration: Aïda Amer/Axios

  1. Health: Nursing homes are still getting pummeledU.S. could hit herd immunity by end of summer 2021 if Americans embrace virus vaccines, Fauci says.
  2. Politics: Pelosi, Schumer call on McConnell to adopt bipartisan $900B stimulus framework.
  3. World: U.K. clears Pfizer-BioNTech vaccine for mass rollout — Putin says Russia will begin large-scale vaccination next week.
  4. Business: Investors are finally starting to take their money out of safe-haven Treasuries.
  5. Sports: The end of COVID’s grip on sports may be in sight.

Pelosi, Schumer call on McConnell to adopt bipartisan $900B stimulus framework

House Speaker Nancy Pelosi on Nov. 20. Photo: Drew Angerer/Getty Images

House Speaker Nancy Pelosi (D-Calif.) and Senate Minority Leader Chuck Schumer (D-N.Y.) on Wednesday urged Senate Majority Leader Mitch McConnell (R-Ky.) to use a $908 billion bipartisan coronavirus relief framework as a basis for jumpstarting negotiations.

Why it matters: The framework, introduced by a group of bipartisan senators on Tuesday, calls for significantly less funding than Pelosi had previously demanded — a sign that Democrats are ready to further compromise as millions of Americans endure economic hardship.