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A man records the 2-mile Walk to End Alzheimer's finish in Huntington Beach on Saturday, October 6, 2018. Photo: Mindy Schauer/Digital First Media/Orange County Register via Getty Images

Scientists are seeking early diagnostics for Alzheimer's that could predict who is likely to develop the disease before noticeable symptoms materialize. In recent months, a large study was published showing that certain PET scans can lead to more accurate diagnoses, while other researchers are looking for disease biomarkers that may be evident in the eye, spinal fluid or the blood.

Why it matters: Alzheimer's, which is expected to affect 14 million Americans by 2060, starts decades before outward signs are indicated. While high-profile drug treatment trial failures, which were aimed at halting the degenerative disease, have occurred recently, scientists believe there are steps people can take that may help delay memory loss or alleviate other symptoms — and catching Alzheimer's early may be especially beneficial.

Background:

  • A major focus of research is on possible drug treatments targeting the clumps of protein (amyloid plaques) and tangled bundles of fibers (tau proteins) in the brain, but with recent trial failures, debate has sharpened over whether treatment research needs to look elsewhere.
  • Even if some researchers believe plaques and tau proteins may not play a causative role, they are considered hallmarks of the disease that diagnostics work is built around.

What's new: Howard Fillit, founding executive director and chief science officer of the Alzheimer’s Drug Discovery Foundation, tells Axios:

  • "There's a lot of excitement in the field right now ... despite the [recent failure in some] clinical trials. There's over 100 studies being conducted now, with roughly half in amyloid and tau research."
  • A large study of 11,049 people with mild cognitive impairment (MCI) or dementia published in JAMA Tuesday shows PET scans identifying amyloid plaques changed clinical care, such as drugs and counseling, by roughly two-thirds.
  • Fillit says that if Medicare would allow the tool, he believes people would not only get the proper diagnosis and symptom alleviation they need, but clinical trials would improve by having a larger and definite pool of Alzheimer's patients to study.

Other exciting developments in the works, Fillit says, are tests of early diagnostics in the eyes, blood and spinal fluid that look for amyloids and tau, plus inflammatory and neurodegeneration markers. He expects a blood test in a couple years and says "this is a really exciting time for biomarkers in this space."

Biomarkers are something — such as amyloids — that can be measured and indicate the possible presence of a disease. Fillit points to...

Meanwhile, Jeff and MacKenzie Bezos joined the Diagnostics Accelerator formed over the summer to develop novel biomarkers for the early detection of Alzheimer's, bringing the total funding for new grants over the next 3 years to $50 million, ADDF announced Tuesday.

The bottom line: Billions are being spent by the U.S. government and biotech companies to understand the cause and to pin down better diagnostics and treatments. "Alzheimer's will look like cancer [research] soon," Fillit says. "We will have precision medicine."

Go deeper:

Go deeper

Chris Cuomo accuser: On-air "hypocrisy" spurred report

Journalist Chris Cuomo. Photo: Gilbert Carrasquillo/GC Images

A woman who accused fired CNN journalist Chris Cuomo of sexual misconduct said Sunday she decided to come forward after learning of his comments about women who made similar accusations about his brother. He denies her allegations.

Why it matters: Her attorney Debra Katz said in a statement that she heard "the hypocrisy" of his on-air words about his brother, former New York Gov. Andrew Cuomo, and was "disgusted by his efforts to try to discredit these women," so "retained counsel to report his serious sexual misconduct against her to CNN."

Updated 4 hours ago - Politics & Policy

Omicron dashboard

Illustration: Shoshana Gordon/Axios

  1. Health: CDC director says number of U.S. Omicron cases "likely to rise" — Two years of COVID-19 — Prior coronavirus infections may not protect well against Omicron.
  2. Vaccines: Data demonstrates most-vaccinated counties less vulnerable to worst of COVID — Omicron adds urgency to vaccinating world — Omicron fuels the case for COVID boosters.
  3. Politics: Nevada to impose insurance surcharge on unvaccinated state workers — New Jersey GOP lawmakers defy statehouse COVID policy — Oklahoma sues Biden administration over Pentagon vaccine mandate.
  4. World: Vaccine mandates lose steam in the U.S. while Europe doubles downWHO: Delta health measures help fight Omicron — COVID cases surge in South Africa in sign Omicron wave is coming.
  5. Variant tracker: Where different strains are spreading.

Vulnerable Democrats: Less Trump talk

Illustration: Aïda Amer/Axios

Vulnerable House Democrats are convinced they need to talk less about the man who helped them get elected: President Trump.

Why it matters: Democrats are privately concerned nationalizing the 2022 mid-terms with emotionally-charged issues — from Critical Race Theory to Donald Trump's role in the Jan. 6 insurrection — will hamstring their ability to sell the local benefits of President Biden's Build Back Better agenda.