Sign up for our daily briefing

Make your busy days simpler with Axios AM/PM. Catch up on what's new and why it matters in just 5 minutes.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on the day's biggest business stories

Subscribe to Axios Closer for insights into the day’s business news and trends and why they matter

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios Pro Rata

Dive into the world of dealmakers across VC, PE and M&A with Axios Pro Rata. Delivered daily to your inbox by Dan Primack and Kia Kokalitcheva.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sports news worthy of your time

Binge on the stats and stories that drive the sports world with Axios Sports. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Tech news worthy of your time

Get our smart take on technology from the Valley and D.C. with Axios Login. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Get the inside stories

Get an insider's guide to the new White House with Axios Sneak Peek. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Denver news?

Get a daily digest of the most important stories affecting your hometown with Axios Denver

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Des Moines news?

Get a daily digest of the most important stories affecting your hometown with Axios Des Moines

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Twin Cities news?

Get a daily digest of the most important stories affecting your hometown with Axios Twin Cities

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Tampa Bay news?

Get a daily digest of the most important stories affecting your hometown with Axios Tampa Bay

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Charlotte news?

Get a daily digest of the most important stories affecting your hometown with Axios Charlotte

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Nashville news?

Get a daily digest of the most important stories affecting your hometown with the Axios Nashville newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Columbus news?

Get a daily digest of the most important stories affecting your hometown with the Axios Columbus newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Dallas news?

Get a daily digest of the most important stories affecting your hometown with the Axios Dallas newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Austin news?

Get a daily digest of the most important stories affecting your hometown with the Axios Austin newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Atlanta news?

Get a daily digest of the most important stories affecting your hometown with the Axios Atlanta newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Philadelphia news?

Get a daily digest of the most important stories affecting your hometown with the Axios Philadelphia newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Chicago news?

Get a daily digest of the most important stories affecting your hometown with the Axios Chicago newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios NW Arkansas

Stay up-to-date on the most important and interesting stories affecting NW Arkansas, authored by local reporters

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top DC news?

Get a daily digest of the most important stories affecting your hometown with the Axios DC newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Gym lessons for residents with Alzheimer's disease in a French facility. Photo: BSIP/UIG via Getty Images

The dramatic increase in funding for Alzheimer's research in recent years is spurring hope that scientists will be able to discover the elusive biological causes of the disease.

Why it matters: A total of 5.7 million Americans currently live with Alzheimer's and, as baby boomers age, 14 million are expected to develop the illness by 2050. In response, the U.S. has dramatically stepped up funding for Alzheimer’s research, from $400 million a year to over $2 billion annually, a fact that Bill Gates touted in his end-of-year blog.

"The brain really is the most complex organ of the body. We have not yet figured out the biological mechanical underpinnings of the disease... [But] we're incredibly excited about the new funding... It'll really allow us to expand the hypotheses to investigate for this disease."
— Rebecca Edelmayer, director of scientific engagement, Alzheimer's Association.

What's new: Recent research looks at possible causal links, including...

1. Bacteria and viruses. A study out Wednesday says there could be a connection to bacteria that causes gingivitis, Porphyromonas gingivalis.

  • The bacteria causes toxic enzymes, called gingipains, that were found to cause dementia-like symptoms in mice and have been discovered in the brain samples of Alzheimer's patients.
  • But not everyone's convinced it causes Alzheimer's. Edelmayer says several studies are examining the role of bacteria and/or viruses found in the brain of patients — the problem is that larger studies are needed to see if those pathogens caused Alzheimer's, or if they entered the brain because of damage caused by the disease already.

2. Lifestyle. Researchers at Washington University School of Medicine in St. Louis announced Thursday they found sleep deprivation increases two proteins — tau and amyloid-beta, which have been linked to brain damage and dementia.

  • While she couldn't comment on this study, Edelmayer says there's been connections found between Alzheimer's and a failure to maintain a healthy lifestyle. This includes sleep and controlling blood pressure and blood sugar levels.
  • AA recently started a two-year clinical trial called U.S. Pointer, which involves over 2,000 people between the ages of 60 and 70 to examine lifestyle interventions.
  • "The point is that there are things we could be doing today that could lower the risk of cognitive decline," Edelmayer says.

3. Genetic mutations. There have been many genes linked to the disorder, and now there are take-home blood tests that could look for genes linked to Alzheimer's, like APOE-4.

  • But, Edelmayer points out there are the rare inherited genes that cause familial Alzheimer's and there are multiple genes that may indicate a greater risk for Alzheimer's, but don't necessarily mean the person will get the disease.
  • AA's stance is that people taking home tests for genetic markers should do so with a genetic counselor who can explain what the results really mean.

4. Inflammation. There may be a role played by inflammation of blood vessels including those in the blood-brain barrier that protects the brain.

  • A new study, called BEACON, expects to start clinical trials in April to look at how one type of inflammation in the brain’s blood vessels may affect brain development.
  • They will test if the drug Dabigatran, typically used to prevent strokes, will break the cycle of inflammation.

The bottom line: Researchers are working to narrow down the still wide range of possible biological causes of this disease, with a big boost in available resources.

Go deeper:

Go deeper

Updated 43 mins ago - Economy & Business

The billionaire balloon

Data: World Inequality Report 2022; Chart: Axios Visuals

The super-rich are getting stupid rich: New data out today shows the share of global wealth held by the richest slice of humanity swelled by almost a full percentage point during the pandemic.

Driving the news: The top 0.01% of individuals now hold about 11% of the world's wealth, compared to just over 10% in 2020, according to the "World Inequality Report 2022," written by Lucas Chancel, Thomas Piketty, Emmanuel Saez and Gabriel Zucman.

Tina Reed, author of Vitals
44 mins ago - Health

Omicron gives a shot to boosters

Expand chart
Data: CDC; Chart: Will Chase/Axios

Vaccination rates have ticked higher since the discovery of the Omicron variant, CDC data shows.

By the numbers: The seven-day average for vaccinations in the U.S. reached about 1.8 million on Monday, up from an average of about 1.3 million a month ago.

Scoop: Over 200 papers quietly sue Big Tech

Illustration: Allie Carl/Axios

Newspapers all over the country have been quietly filing antitrust lawsuits against Google and Facebook for the past year, alleging the two firms monopolized the digital ad market for revenue that would otherwise go to local news. 

Why it matters: What started as a small-town effort to take a stand against Big Tech has turned into a national movement, with over 200 newspapers involved across dozens of states.