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New today: House Speaker Paul Ryan won’t run for re-election, a decision whose timing was first reported by Axios’ Jonathan Swan. Rep. Dennis Ross (R-FL) is also retiring, the Tampa Bay Times reports.

By time the midterm elections roll around, there will be at least 58 vacated House seats up for grabs — two-thirds of those are currently held by Republicans. The openings are significant because incumbents have outperformed non-incumbents of the same party in similar districts by about seven points in the last decade or so, per the New York Times.

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Notes: The Cook Partisan Voter Index is a measure of how liberal or conservative a district leans based on the two most recent elections. Pennsylvania PVI and vote margins reflect the 2016 district map prior to being redrawn; Data: Daily Kos Elections and Cook Political Reports; Chart: Chris Canipe / Axios

Go deeper

Dion Rabouin, author of Markets
1 hour ago - Economy & Business

How the tech stock selloff is hurting average Americans

Expand chart
Data: FactSet; Chart: Axios Visuals

Investors holding the ultra-popular Nasdaq 100 and S&P 500 index funds have been hard hit over the last two weeks as tech shares have been roiled by rising U.S. Treasury yields.

Why it matters: Even though the economy is growing and many U.S. stocks are performing well, most investors are seeing their wealth decline because major indexes no longer reflect the overall economy or even a broad swath of public companies — they reflect the performance of a few of the country's biggest companies.

2 hours ago - World

UN rights chief: At least 54 killed, 1,700 detained since Myanmar coup

A Feb. 7 protest in Yangon, Myanmar. Photo: Getty Images/Getty Images

Police and military officers in Myanmar have killed at least 54 people during anti-coup protests, while "arbitrarily" detaining over 1,700 people, United Nations Human Rights Commissioner Michelle Bachelet said Thursday.

Why it matters: Protesters have demonstrating across Myanmar for nearly a month, demanding the restoration of democracy after the country's military leaders overthrew its democratically elected government on Feb. 1.

3 hours ago - Health

The danger of a fourth wave

Expand chart
Data: The COVID Tracking Project, state health departments; Note: Anomalous Arkansas case data from Feb. 28 was not included in the calculated change; Map: Andrew Witherspoon/Axios

The U.S. may be on the verge of another surge in coronavirus cases, despite weeks of good news.

The big picture: Nationwide, progress against the virus has stalled. And some states are ditching their most important public safety measures even as their outbreaks are getting worse.