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Table: Andrew Witherspoon/Axios

Andy Reid has built an offensive juggernaut in Kansas City thanks to an otherworldly QB and the NFL's fastest group of receivers. He also happens to be the sport's most valuable play-caller.

By the numbers: The Chiefs scored on nearly half of their possessions this season, trailing only the Ravens. They also faced the third-fewest third downs of any team — and led the NFL in third-down conversion rate anyway.

  • Yes, it may be true that the Chiefs have to set an alarm on their phone to remind themselves to run the football. But we've reached the point now where it's like ... why wouldn't you put the ball in Mahomes' hands every snap?

What they're saying: Chiefs WR coach Greg Lewis spoke about Reid's study habits and attention to detail, saying he has "a beautiful mind."

"He studies college games, high school games, CFL games, European games. He'll go look at stuff from 1910. ... He is able to compartmentalize everything then bring it out at the right moment [and] put it in terms everyone understands, and that's special."

On defense... the 49ers' defensive line faces a unique challenge: generate constant pressure on Mahomes while playing disciplined enough to contain him and keep him from extending plays outside the pocket.

The bottom line: This is the marquee matchup of Super Bowl LIV: Mahomes and his speedy receivers vs. Bosa, Buckner and San Francisco's fearsome front.

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Ina Fried, author of Login
6 mins ago - Science

CRISPR pioneer: "Science is on the ballot" in 2020

Photo: "Axios on HBO"

In her three decades in science, Jennifer Doudna said she has seen a gradual erosion of trust in the profession, but the recent Nobel Prize winner told "Axios on HBO" that the institution itself has been under assault from the current administration.

  • "I think science is on the ballot," Doudna said in the interview.

Why it matters: That has manifested itself in everything from how the federal government approaches climate change to the pandemic.

Ted Cruz doesn't think the Hunter Biden attacks are working

Republican Sen. Ted Cruz told "Axios on HBO" he doesn't think the Trump campaign's focus on the Biden family's business dealings are having any sway with voters.

The big picture: After watching the Trump-Biden debate with "Axios on HBO" on Thursday night, Cruz said he thought Trump had done very well. But when asked whether he thought voters were moved by the release of the Hunter Biden emails, Cruz replied, "I don't think it moves a single voter."

Ilhan Omar: The Squad expects liberal turn from Biden after election

Rep. Ilhan Omar told "Axios on HBO" that given the way progressives have shaped Joe Biden's policy platform, she and other members of "The Squad" expect a liberal turn from him if he's elected.

Why it matters: Progressives have largely refrained from publicly criticizing Biden in the lead-up to the election, even though he hasn't signed on to their most far-reaching policies. Instead, they're focusing solely on beating Trump.