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Data: JAMA Network report; Chart: Naema Ahmed/Axios

The opioid epidemic is most deadly and growing fastest in the eastern half of the United States, according to a new study in the Journal of the American Medical Association.

Why it matters: Recognizing how the opioid epidemic presents in each state — which drugs are being used and whether or not the problem is getting worse — is critical to getting the policy response right.

Details: Synthetic opioids, like fentanyl, are far and away the leading contributor to the rising death toll.

  • The places hit hardest by synthetics are not necessarily the same ones hit hardest by prescription opioids in the first wave of the epidemic.

Go deeper ... The border's deadliest threat: opioids

Go deeper

Updated 11 mins ago - Politics & Policy

Coronavirus dashboard

Illustration: Sarah Grillo/Axios

  1. Politics: Biden ahead in Wisconsin, Michigan as cases surge in the Midwest.
  2. Health: Surge "is real" and not just caused by more tests, Trump's testing czar saysMask mandates help control rise in hospitalizations Some coronavirus survivors have "autoantibodies."
  3. Business: Surge is sinking consumer confidence Testing is a windfall.
  4. World: Europe faces "stronger and deadlier" coronavirus wave France imposes lockdown as Macron warns of overwhelming second COVID wave Germany to close bars and restaurants for a month.
  5. Sports: Boston Marathon delayed as COVID-19 surges MLB to investigate Dodgers player who joined celebration after positive COVID test.

What the 2020 election means for science

Illustration: Sarah Grillo/Axios

The 2020 presidential election presents two stark paths for the direction of future-focused scientific research.

Why it matters: Science is a long game, with today's breakthroughs often stemming from research carried out decades ago, often with government help. That means the person who occupies the White House over the next four years will help shape the state of technology for decades into the future.

Zeta, now a Category 2 Hurricane, makes landfall on Louisiana coast

The probable path of Zeta, per the National Hurricane Center. Photo: NHC/NOAA

Zeta, classified as a "significant" Category 2 hurricane, made landfall along the southeastern coast of Louisiana on Wednesday evening, according to the National Hurricane Center.

The state of play: Louisiana Gov. John Bel Edwards (D) requested a pre-landfall Emergency Declaration in a letter to President Trump on Tuesday. The hurricane is producing 110-mph maximum sustained winds and stronger gusts. The core of Zeta — including its destructive eyewall — moved ashore near Cocodrie.