Nov 29, 2018

Gene editing moves into a frightening new stage

Illustration: Aïda Amer/Axios

The possibility that babies from genetically edited embryos may have been born in China has pushed the science into a frightening new stage. It has become more real, even if scientists don't think it should be done in this way.

Why it matters: If nothing else, the scientific world is now talking more seriously about the implications of gene editing embryos than they did when it was just a prospect.

The international reaction has been mostly outrage.

  • He Jiankui, the scientist who claims he edited and implanted the embryos that resulted in a twin birth earlier this month, spoke earlier this week at a symposium in Hong Kong about how and why he decided to buck international guidelines from the U.S. and the U.K. on experimenting with editing embryos.
  • He stirred even more dismay when he mentioned the possibility of a second pregnancy.

Between the lines: Not everyone viewed it as a complete disaster. In fact, some scientists are ready to move ahead.

  • Harvard Medical School's George Daley suggested at the conference in Hong Kong that it's time to reconsider the massive amounts of research that was done over the past three years since the international guidance was created.
  • "Just because the first steps into a new technology are missteps doesn't mean we shouldn't step back, restart and think about a plausible" method of moving forward, Daley said.

What they're saying: There are concerns about the safety and efficacy of editing genes in adults, and editing embryos raises an even bigger ethical concern: The genetic changes and all the unknowns around them can be passed down to future generations.

  • Patrick David Hsu of the Salk Institute tells Axios, "This is bad, irresponsible science."
  • Eric Topol of Scripps Research Translational Institute says: "This was the fear — that someone, someday, would do something before it was ready. ... But, for the most part, there was international consensus that we were not ready."
  • National Institutes of Health director Francis Collins made it clear on Twitter that he wants to slow it down: "The need for development of binding international consensus on setting limits for this kind of research, now being debated in Hong Kong, has never been more apparent. Without such limits, the world will face the serious risk of a deluge of similarly ill-considered and unethical projects."

What to watch: Scientists are cautious about predicting what the impact will be, in part because the details of this claim are thin. The way medical ethicist Jonathan Moreno from the University of Pennsylvania talks about it illustrates the conflict: He's aware of its potential to change the trajectory of science, but also skeptical that this particular experiment is real.

  • Moreno says the situation reminds him of other times in history where there were tremors in the science world, like the death of 18-year-old Jesse Gelsinger in 1999 from a gene therapy trial that led to years of diminished research.
  • "I think it could be a huge event, like the Gelsinger death ... especially if there really is a third baby. On the other hand, he hasn't [published] anything, so we can't be sure."

The bottom line: The alarm over what could be next is real. Moreno says there's concern it could hinder current research projects, and Hsu says there's hope it may spur more needed transparency in research. But the science is moving forward, and we're all going to have to grapple with what's next.

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Trump accuses Twitter of interfering in 2020 election

President Trump speaks to the press as he departs the White House in Washington, D.C., on Thursday. Photo: Mandel Ngan/Getty Images

President Trump responded via tweets Tuesday evening to Twitter fact-checking him for the first time on his earlier unsubstantiated posts claiming mail-in ballots in November's election would be fraudulent.

What he's saying: "Twitter is now interfering in the 2020 Presidential Election.They are saying my statement on Mail-In Ballots, which will lead to massive corruption and fraud, is incorrect, based on fact-checking by Fake News CNN and the Amazon Washington Post," the president tweeted. "Twitter is completely stifling FREE SPEECH, and I, as President, will not allow it to happen!"

Editor's note: This is a developing news story. Please check back for updates.

20 mins ago - Politics & Policy

Coronavirus dashboard

Illustration: Aïda Amer/Axios

  1. Global: Total confirmed cases as of 7:30 p.m. ET: 5,559,130 — Total deaths: 348,610 — Total recoveries — 2,277,087Map.
  2. U.S.: Total confirmed cases as of 7:30 p.m. ET: 1,679,419 — Total deaths: 98,852 — Total recoveries: 384,902 — Total tested: 14,907,041Map.
  3. Federal response: DOJ investigates meatpacking industry over soaring beef pricesMike Pence's press secretary returns to work.
  4. Congress: House Republicans to sue Nancy Pelosi in effort to block proxy voting.
  5. Business: How the new workplace could leave parents behind.
  6. Tech: Twitter fact-checks Trump's tweets about mail-in voting for first timeGoogle to open offices July 6 for 10% of workers.
  7. Public health: CDC releases guidance on when you can be around others after contracting the coronavirus.
  8. What should I do? When you can be around others after contracting the coronavirus — Traveling, asthma, dishes, disinfectants and being contagiousMasks, lending books and self-isolatingExercise, laundry, what counts as soap — Pets, moving and personal healthAnswers about the virus from Axios expertsWhat to know about social distancingHow to minimize your risk.
  9. Other resources: CDC on how to avoid the virus, what to do if you get it, the right mask to wear.

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Updated 46 mins ago - Politics & Policy

Twitter fact-checks Trump's tweets for first time

President Trump briefs reporters in the Rose Garden on May 26. Photo: Brendan Smialowski/AFP via Getty Images

Twitter fact-checked two of President Trump's unsubstantiated tweets that mail-in ballots in the 2020 election would be fraudulent for the first time on Tuesday, directing users to "get the facts" through news stories that cover the topic.

Why it matters: Twitter and other social media platforms have faced criticism for not doing enough to combat misinformation, especially when its propagated by the president.