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Humira, the blockbuster anti-inflammatory drug that is routinely blasted on TV commercials, netted $13.6 billion in gross U.S. sales last year — the most of any brand-name prescription drug. The 20 top-selling drugs generated more than $98 billion in gross U.S. sales in 2016, or about $20 billion more than the U.S. Department of Transportation's budget from last year.

Expand chart
Data: QuintilesIMS Institute; Chart: Chris Canipe / Axios

The bottom line: The biggest drug sellers, which are heavily advertised on TV, treat conditions that affect millions of Americans. But the growth in pharmaceutical spending continues to be well above inflation, putting many people in a bind when they pick up their medicine at the pharmacy.

The data: QuintilesIMS, a pharmaceutical research firm, collected the data in an annual report. The totals are gross figures, so they do not factor in rebates and discounts that are negotiated with insurers and pharmacy benefit managers, nor do they include coupons and promotions.

Rebates between drug manufacturers and middlemen are not public information. But here's some context: Humira netted $13.6 billion in gross U.S. revenue. AbbVie, the company that makes Humira, reported $10.4 billion in net U.S. sales for the drug in its audited financials. That indicates rebates and discounts for Humira could have been around 25%.

  • AbbVie told analysts at Leerink Partners that peak global revenue for the drug will hit $20 billion before biosimilar versions hit the market in 2022 and eat into sales. The company also believes the Trump administration won't do anything to affect drug pricing decisions.
  • Hepatitis C drug Harvoni has busted onto the scene. The drug, made by Gilead Sciences, brought in $10 billion of gross sales in 2016 and has sparked debate over how much a drug should cost if it cures a disease.
  • The drug with the fifth-highest sales was Remicade, made by Johnson & Johnson. Pfizer is suing Johnson & Johnson, alleging the company has blocked Pfizer's cheaper biosimilar version of Remicade from penetrating the market.

Go deeper

Miriam Kramer, author of Space
9 hours ago - Science

China makes history with successful Mars landing

A model of the Tianwen-1 Mars rover is displayed during an exhibition at the National Museum of China in Beijing. Photo: Wang Zhao/AFP via Getty Images

A Chinese lander carrying a rover successfully touched down on Mars for the first time, state media reports.

Why it matters: This is the first time China has landed a spacecraft on another planet, and it launches the nation into an elite club of only a few space agencies to successfully make it to the Martian surface.

10 hours ago - World

UN: 10,000 Palestinians displaced in Gaza as Israel-Hamas fighting escalates

A Palestinian woman walks after she collects her belongings inside her damaged house following an Israeli air in the northern Gaza Strip. Photo: Ahmed Zakot/SOPA Images/LightRocket via Getty Images)

The United Nations warned Friday that ongoing fighting between Israel and Hamas "has the potential to unleash an uncontainable security and humanitarian crisis," in not only the occupied Palestinian territories and Israel, but "the region as a whole."

The big picture: More than 125 Palestinians, including 31 children have been killed in Gaza since fighting began Monday, per the Palestinian Ministry of Health. Eight people, including two children, have been killed in Israel, Reuters reported, citing Israeli authorities.

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