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Mark Zuckerberg (L) and Sean Parker (R). Photos: Steven Senne/AP, Axios video

Sean Parker, the founding president of Facebook, gave me a candid insider's look at how social networks purposely hook and potentially hurt our brains.

Be smart: Parker's I-was-there account provides priceless perspective in the rising debate about the power and effects of the social networks, which now have scale and reach unknown in human history. He's worried enough that he's sounding the alarm. Parker, 38, now founder and chair of the Parker Institute for Cancer Immunotherapy, spoke yesterday at an Axios event at the National Constitution Center in Philadelphia, about accelerating cancer innovation. In the green room, Parker mentioned that he has become "something of a conscientious objector" on social media. By the time he left the stage, he jokingly said Mark Zuckerberg will probably block his account after reading this:

"When Facebook was getting going, I had these people who would come up to me and they would say, 'I'm not on social media.' And I would say, 'OK. You know, you will be.' And then they would say, 'No, no, no. I value my real-life interactions. I value the moment. I value presence. I value intimacy.' And I would say, ... 'We'll get you eventually.'""I don't know if I really understood the consequences of what I was saying, because [of] the unintended consequences of a network when it grows to a billion or 2 billion people and ... it literally changes your relationship with society, with each other ... It probably interferes with productivity in weird ways. God only knows what it's doing to our children's brains." "The thought process that went into building these applications, Facebook being the first of them, ... was all about: 'How do we consume as much of your time and conscious attention as possible?'" "And that means that we need to sort of give you a little dopamine hit every once in a while, because someone liked or commented on a photo or a post or whatever. And that's going to get you to contribute more content, and that's going to get you ... more likes and comments." "It's a social-validation feedback loop ... exactly the kind of thing that a hacker like myself would come up with, because you're exploiting a vulnerability in human psychology.""The inventors, creators — it's me, it's Mark [Zuckerberg], it's Kevin Systrom on Instagram, it's all of these people — understood this consciously. And we did it anyway." P.S. Parker, on life science allowing us to "live much longer, more productive lives": "Because I'm a billionaire, I'm going to have access to better health care so ... I'm going to be like 160 and I'm going to be part of this, like, class of immortal overlords. [Laughter] Because, you know the [Warren Buffett] expression about compound interest. ... [G]ive us billionaires an extra hundred years and you'll know what ... wealth disparity looks like."Go deeper: See the video of Parker's comments.

Go deeper: Joe Biden rips Trump's "phony nationalism".

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Go deeper

Blinken faces Senate on Afghanistan after 5+ hour grilling before House panel

Photo: Stefani Reynolds/Bloomberg via Getty Images

Secretary of State Antony Blinken is testifying Tuesday before the Senate Foreign Relations Committee, where he'll face a second day of interrogation from Republican lawmakers highly critical of the Biden administration's withdrawal from Afghanistan.

The big picture: In more than five hours of testimony before the House Foreign Affairs Committee Monday, Blinken calmly defended nearly every aspect of the withdrawal and evacuation effort — refusing to concede it could have been handled differently even as he faced intense criticism and calls to resign from furious Republicans.

A scary, but normal market phenomenon

Illustration: Rae Cook/Axios

The S&P 500 is just below its record high. But most stocks in the index are actually down significantly, which has some concerned.

Why it matters: This implies that the gains driving the market index to record highs are not evenly distributed. But, it’s also not an unusual dynamic in the S&P’s recent history.

3 hours ago - World

Putin isolating after members of inner circle contract coronavirus

Russian President Vladimir Putin speaking in Moscow on Sept. 13. Photo: Mikhail Svetlov/Getty Images

Russian President Vladimir Putin will isolate himself for an undisclosed amount of time after people in his inner circle tested positive for the coronavirus, the Kremlin said Tuesday.

Why it matters: Putin has tested negative for the virus and received his second dose of the Russian coronavirus vaccine, Sputnik V, in April, according to ABC News.