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A City of San Francisco worker cleaning the street. Photo: Lea Suzuki/The San Francisco Chronicle via Getty Images

The City of San Francisco announced Wednesday that it will require all of its roughly 35,000 employees to be vaccinated against COVID-19 — and impose penalties that may include getting fired on workers who refuse.

Why it matters: San Francisco is the first major city in the U.S. to announce plans for a coronavirus vaccine mandate.

The big picture: There has been some resistence to vaccine mandates elsewhere in the U.S., notably in Texas where 153 Houston Methodist Hospital workers resigned or were fired over the requirement this month.

  • But San Francisco has one of the highest COVID-19 vaccination rates in the U.S.

By the numbers: Data released on June 11 shows 80% of eligible residents had received at least one dose.

  • Nearly 70% of all San Franciscans had been fully vaccinated by this date.

What to watch: The mandate will take effect when a COVID-19 vaccine receives full authorization from the Food and Drug Administration, rather than the current emergency use one, per the San Francisco Chronicle.

Go deeper

Newsom orders COVID-19 vaccine mandate for California students

Students attending school in L.A. Unified School District. Photo: Robyn Beck / AFP

California Gov. Gavin Newsom (D) announced on Friday that all eligible public and private school students will be mandated to receive a COVID-19 vaccine, once it has been given final approval from the FDA.

Why it matters: This is the first K-12 COVID-19 vaccine mandate, the Los Angeles Times reports.

Updated 14 hours ago - Politics & Policy

Coronavirus dashboard

Illustration: Aïda Amer/Axios

  1. Vaccines: CDC says some immunocompromised people can get fourth COVID shot — FDA panel endorses Pfizer vaccines for 5-11 year olds — Moderna says vaccine shows strong immune response in kids
  2. Health: COVID cases, deaths at meat plants were far higher than previously thought — 96% of Tyson Foods employees vaccinated ahead of mandate deadline — U.S. releases updated vaccination, testing rules for foreign travelers
  3. Politics: Louisiana lifts mask mandate except for some schools — Alabama governor orders state agencies to fight federal vaccine mandate — Axios-Ipsos poll: Confidence in Biden COVID recovery tumbles
  4. Education: Benefits of vaccine for children outweigh risks, FDA says — Education secretary reveals limits to Biden’s mask push on states — LA extends deadline for school employee vaccinations.
  5. Variant tracker: Where different strains are spreading.
Sep 30, 2021 - Axios Denver

Denver braces for wave of exits over city employee vaccine mandate

Illustration: Sarah Grillo/Axios

Time has run out.

Driving thew news: Denver Mayor Michael Hancock’s deadline has arrived for city workers and some "high-risk" private sector employees to get vaccinated against COVID-19.