While tapering patients taking prescription opioids off of the medication is associated with a lower risk of overdose if the patient stops taking the drug, it can also lead to increased risks of overdose if it leads to the patient switching up dosages, according to a new JAMA study.

Why it matters: This is yet another obstacle to solving the opioid epidemic, and shows how the best intentions can be dangerous: Even trying to get patients to quit taking legal opioids can backfire and lead to overdose.

  • The study found that changing a patient's opioid dosage increased the risk of overdose. But it also found that discontinuation of opioids reduced the risk.
  • Patients often take decreasing dosages of a drug as a way of weaning themselves off of it. But sometimes, if they begin to go through withdrawal or their pain increases, the patient could then ask for a dose increase or seek opioids elsewhere.

Go deeper: Lowering prescription opioid misuse won't stop the opioid crisis

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Facebook boycott organizers share details on their Zuckerberg meeting

Facebook is in the midst of the largest ad boycott in its history, with nearly 1,000 brands having stopped paid advertising in July because they feel Facebook hasn't done enough to remove hate speech from its namesake app and Instagram.

Axios Re:Cap spoke with the boycott's four main organizers, who met on Tuesday with CEO Mark Zuckerberg and other top Facebook executives, to learn why they organized the boycott, what they took from the meeting, and what comes next.

Boycott organizers slam Facebook following tense virtual meeting

Illustration: Sarah Grillo/Axios

Civil rights leaders blasted Facebook's top executives shortly after speaking with them on Tuesday, saying that the tech giant's leaders "failed to meet the moment" and were "more interested in having a dialogue than producing outcomes."

Why it matters: The likely fallout from the meeting is that the growing boycott of Facebook's advertising platform, which has reached nearly 1000 companies in less than a month, will extend longer than previously anticipated, deepening Facebook's public relations nightmare.

Steve Scalise PAC invites donors to fundraiser at Disney World

Photo: Kevin Lamarque-Pool/Getty Images

House Minority Whip Steve Scalise’s PAC is inviting lobbyists to attend a four-day “Summer Meeting” at Disney World's Polynesian Village in Florida, all but daring donors to swallow their concern about coronavirus and contribute $10,000 to his leadership PAC.

Why it matters: Scalise appears to be the first House lawmakers to host an in-person destination fundraiser since the severity of pandemic became clear. The invite for the “Summer Meeting” for the Scalise Leadership Fund, obtained by Axios, makes no mention of COVID-19.