Jessica Kourkounis / AP

Drugs approved in recent years that can cure hepatitis C may have severe side effects, including liver failure, according to a new report by the Institute for Safe Medication Practices. The report, which the NYT has analyzed in depth, looks at 9 popular antiviral drugs, including the widely used Sovaldi and Harvoni — both made by Gilead Sciences and priced at $1k per pill. The drugs have been successful for many patients in curing the disease within 12 weeks.

Disclaimer: The number of risks appear relatively low, and the findings are not conclusive. But experts say the report is a warning that shouldn't be ignored. Thomas Moore, an author of the report, said the study reflects a larger question about the drug approval process. Approval for the newer hepatitis C drugs was expedited because better treatments were so badly needed.

Why it matters: Hepatitis C drugs like Sovaldi carry a huge price tag, but they've also been a point of pride for the drug industry — since they can cure a disease that wasn't curable before. That, in their view, was a good justification for the price. But if the drugs cause horrible side effects, it may be harder to make that case.

Go deeper

Dion Rabouin, author of Markets
28 mins ago - Economy & Business

Coronavirus surge is sinking consumer confidence

Data: Hamilton Place Strategies, CivicScience; Chart: Axios Visuals

The rise in coronavirus cases in certain parts of the U.S. is stunting confidence across the country, a crop of new reports show.

Driving the news: After stalling during the previous two-week period, overall economic sentiment declined for the first time in two months, according to the Economic Sentiment Index, a biweekly survey from data firm CivicScience and Hamilton Place Strategies (HPS).

Updated 2 hours ago - Politics & Policy

Coronavirus dashboard

Illustration: Sarah Grillo/Axios

  1. Politics: Obama: Trump is "jealous of COVID's media coverage."
  2. Health: Mask mandates help control the rise in coronavirus hospitalizations. Hospitals face a crush.
  3. Business: Coronavirus testing is a windfall. Winter threat spurs new surge of startup activity.
  4. Media: Pandemic causes TV providers to lose the most subscribers ever.
  5. World: Putin mandates face masks.

The GOP's monstrous math problem

Illustration: Sarah Grillo/Axios

Republicans, win or lose next week, face a big — and growing — math problem.

The state of play: They're relying almost exclusively on a shrinking demographic (white men), living in shrinking areas (small, rural towns), creating a reliance on people with shrinking incomes (white workers without college degrees) to survive.