Sign up for our daily briefing

Make your busy days simpler with Axios AM/PM. Catch up on what's new and why it matters in just 5 minutes.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on the day's biggest business stories

Subscribe to Axios Closer for insights into the day’s business news and trends and why they matter

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Stay on top of the latest market trends

Subscribe to Axios Markets for the latest market trends and economic insights. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sports news worthy of your time

Binge on the stats and stories that drive the sports world with Axios Sports. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Tech news worthy of your time

Get our smart take on technology from the Valley and D.C. with Axios Login. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Get the inside stories

Get an insider's guide to the new White House with Axios Sneak Peek. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Axios on your phone

Get breaking news and scoops on the go with the Axios app.

Download for free.

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Denver news?

Get a daily digest of the most important stories affecting your hometown with Axios Denver

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Des Moines news?

Get a daily digest of the most important stories affecting your hometown with Axios Des Moines

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Twin Cities news?

Get a daily digest of the most important stories affecting your hometown with Axios Twin Cities

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Tampa Bay news?

Get a daily digest of the most important stories affecting your hometown with Axios Tampa Bay

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Charlotte news?

Get a daily digest of the most important stories affecting your hometown with Axios Charlotte

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios NW Arkansas

Stay up-to-date on the most important and interesting stories affecting NW Arkansas, authored by local reporters

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

A health care worker screens a patient for COVID-19 at a drive-through coronavirus testing site on March 18, 2020 in Arlington, Virginia. Photo: Drew Angerer/Getty Images

Some academic labs are continuously reworking their coronavirus tests, or trying to make new tests altogether, in an effort to stay ahead of shortages in the supplies they need to make those tests.

The big picture: The U.S.' testing capacity has expanded as large commercial labs pledge to make tests, but we'll be right back to square one if we run out of the necessary ingredients.

Labs have been sounding the alarm about dwindling supplies of test ingredients like reagents, RNA-extraction kits and the swabs used to take samples from patients.

Driving the news: Stanford's clinical virology lab is in the process of validating its fourth RNA extraction method, medical director Benjamin Pinsky told me.

  • It's not as simple as just swapping one material for another. With each change, the lab has to make sure the test is still accurate.
  • “We have not had to do this, this rapidly with this many components of a particular test in my time in the laboratory," Pinsky said.

The University of California at San Francisco's clinical virology lab is working on five assays — which are essentially test recipes — as a response to supply shortages, medical director Charles Chiu told me, even though it already validated one earlier this month.

Other labs are developing tests with the potential for shortages in mind.

  • "Redundancy is key here," Harvard's Michael Mina said. "We are keeping redundancy very much on the back of our minds... There is a concern that some item might become out of stock and so as soon as we are live with our test, we will start validating other modifications."

Reworking existing tests isn't the only desperate attempt being made to ramp testing up. At-home kits are being developed and sold without FDA approval, the Washington Post reported last night, and testing sites are limiting who can be tested to conserve resources.

The bottom line: Continuously reworking tests isn't a sustainable long-term option. "I know a lot of the manufacturers are reporting that they are ramping up production and that these shortages are short-term, but we’ll have to see if that’s the case," Pinsky said.

  • "But certainly I hope that we don’t have to continue to keep changing reagents on a daily or weekly basis. That would be incredibly challenging for our lab.”

Go deeper

Private colleges across America can't pay their bills

Illustration: Sarah Grillo/Axios

Behind the scenes in colleges across the U.S., institutions are having trouble paying their bills.

Why it matters: There’s a reckoning coming in higher education — especially for smaller, private liberal arts schools — that’s been years in the making. In obvious ways, COVID accelerated some of the trends, but college finances have been hurting for a while.

Caitlin Owens, author of Vitals
49 mins ago - Health

Special report: America's biggest hospitals vs. their patients

Expand chart
Data: JHU; Chart: Will Chase/Axios

More than a quarter of the 100 U.S. hospitals with the highest revenue sued patients over unpaid medical bills between 2018 and mid-2020, according to new research by Johns Hopkins University provided exclusively to Axios.

Why it matters: The report suggests that, rather than being an anomaly, patient lawsuits are relatively common across the country and among the largest providers.

49 mins ago - Health

Most top hospitals charge a more than 5x markup

Expand chart
Data: JHU; Chart: Will Chase/Axios

Some of the hospitals with the highest revenue in the country also have some of the highest prices, charging an average of 10 times more than the actual cost of the care they deliver, according to new research by Johns Hopkins University provided exclusively to Axios.

Why it matters: Hospitals each determine their own charges, or list prices. While few patients ever pay those prices, due to negotiated insurance rates, they do affect the uninsured and, experts say, ultimately influence the overall price we all pay.