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Iranian Supreme Leader Ayatollah Ali Khamenei makes a speech on Monday on the 40th anniversary of the Iran crisis. Photo: Lideri Basn Ofisi/Handout/Anadolu Agency via Getty Images

Thousands of Iranians chanted "death to America" as Iran marked the 40th anniversary of the U.S. Embassy takeover and ensuing hostage crisis in Tehran, with Supreme Leader Ayatollah Ali Khamenei declaring the two countries "implacable foes," Reuters reports.

Why it matters: On Nov. 4, 1979, a group of students stormed the American Embassy in Tehran to demand the extradition of the shah, who was being treated for cancer in the U.S. They took hostages, including 62 Americans, in a crisis that lasted for 444 days and "transfixed America," per AP. The damage in relations it caused between the two countries persists today.

The big picture: Per AP, "Popular anger against the U.S. was rooted in the 1953 CIA-engineered coup that toppled Iran’s elected prime minister and cemented the power of Shah Mohammad Reza Pahlavi." While hostages in the embassy were slowly released, several diplomats escaped with the help of the CIA, as documented in the 2002 film "Argo."

  • Relations have soured further since President Trump withdrew the U.S. from the Iran nuclear deal in 2018 and hit the country with sanctions. Iran later announced the suspension of some of its commitments under the nuclear agreement and the resumption of higher uranium enrichment.

What's next: Secretary of State Mike Pompeo will host an event on Monday that "commemorates the bravery that all former hostages and their families have shown during unimaginable circumstances," the State Department said in a statement.

"It’s unfortunate that this anniversary serves as a reminder of the long history of malign behavior by the Iranian regime and the danger it has posed to the United States and the world over the past 40 years."
— State Department statement

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Driving the news: Fauci, Biden's chief medical adviser, told ABC's George Stephanopoulos on "This Week" that U.S. officials will meet with colleagues from South Africa later on Sunday to try to determine the severity of the cases, as countries scramble to learn more about the variant.

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Why it matters: At a time when roughly 100,000 Russian troops are massing at its border, Ukraine views Nord Stream 2 as an existential threat to its security. The pipeline would circumvent Ukrainian transit infrastructure and deliver Russian gas directly to Germany, eliminating one of the last deterrents Ukraine has against an invasion.