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Iranian Supreme Leader Ayatollah Ali Khamenei makes a speech on Monday on the 40th anniversary of the Iran crisis. Photo: Lideri Basn Ofisi/Handout/Anadolu Agency via Getty Images

Thousands of Iranians chanted "death to America" as Iran marked the 40th anniversary of the U.S. Embassy takeover and ensuing hostage crisis in Tehran, with Supreme Leader Ayatollah Ali Khamenei declaring the two countries "implacable foes," Reuters reports.

Why it matters: On Nov. 4, 1979, a group of students stormed the American Embassy in Tehran to demand the extradition of the shah, who was being treated for cancer in the U.S. They took hostages, including 62 Americans, in a crisis that lasted for 444 days and "transfixed America," per AP. The damage in relations it caused between the two countries persists today.

The big picture: Per AP, "Popular anger against the U.S. was rooted in the 1953 CIA-engineered coup that toppled Iran’s elected prime minister and cemented the power of Shah Mohammad Reza Pahlavi." While hostages in the embassy were slowly released, several diplomats escaped with the help of the CIA, as documented in the 2002 film "Argo."

  • Relations have soured further since President Trump withdrew the U.S. from the Iran nuclear deal in 2018 and hit the country with sanctions. Iran later announced the suspension of some of its commitments under the nuclear agreement and the resumption of higher uranium enrichment.

What's next: Secretary of State Mike Pompeo will host an event on Monday that "commemorates the bravery that all former hostages and their families have shown during unimaginable circumstances," the State Department said in a statement.

"It’s unfortunate that this anniversary serves as a reminder of the long history of malign behavior by the Iranian regime and the danger it has posed to the United States and the world over the past 40 years."
— State Department statement

Go deeper

Updated 13 mins ago - World

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Trump struck several large arms deals with Mohammed bin Salman (L) and Saudi Arabia. Photo: Kevin Dietsch-Pool/Getty Images

The Biden administration has put on hold two big arms deals with Saudi Arabia and the United Arab Emirates which were approved in the final weeks of the Trump administration, a State Department official told Axios.

Why it matters: The sales of F-35 jets and attack drones to the UAE and a large supply of munitions to Saudi Arabia will be paused pending a review. That signals a major policy shift from the Trump era, and may herald sharp tensions with both Gulf countries.

Trump supporter found with pipe bombs accused of plot to attack Democrats

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The FBI believes California Gov. Gavin Newsom (D) and the Bay Area headquarters of Twitter and Facebook were targets of a man facing federal explosives charges, according to a criminal complaint.

Driving the news: Prosecutors charged Ian Benjamin Rogers after finding weapons including five pipe bombs, 49 guns and thousands of rounds of ammunition following a Jan. 15 search of his Napa County home and auto repair business. His alleged goal was to ensure former President Trump remained in office.

4 hours ago - Health

Fauci: COVID vaccine rollout needs to prioritize people of color

Anthony Fauci. Photo: Alex Wong via Getty Images

Infectious disease expert Anthony Fauci highlighted the need to address racial disparities in the COVID-19 vaccination process, per an interview with The New England Journal of Medicine on Wednesday.

What he’s saying: "I think that's the one thing we really got to be careful of. We don't want in the beginning ... most of the people who are getting it are otherwise, well, middle-class white people."