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J. Scott Applewhite / AP

Darrell Issa is the latest in a series of House Republicans to depart Congress after this term, he announced Wednesday. His seat in southern California is particularly vulnerable for the party in 2018, as Hillary Clinton won his district by 7.5 points.

Outlier check: There are now 28 retiring representatives. The average number over the last five election cycles has been 23. Over that time, there has been more attrition from Republicans than from Democrats, however, the 3-to-1 ratio of retiring Republicans to Democrats this cycle is considerable.

Outlier check 2: According to Brookings, the average terms served for retiring members has hovered around 8 over the last 40 years, but dropped to 5 in the 2016 cycle. The average among these 21 Republicans is 9.4.

Note: This list includes retirements and resignations, not those seeking or appointed to a higher office.

A look at the 21 departing Republicans...

Darrell Issa of California:

  • Date announced: Jan. 10
  • Terms: 9 terms
  • 2016 margin of victory: 0.6 points
  • 2016 presidential: Clinton by 7.5 points

Ed Royce of California (Chair of Foreign Affairs Committee):

  • Date announced: Jan. 8
  • Terms: 13 terms
  • 2016 margin of victory: 14 points
  • 2016 presidential: Clinton by 9 points

Gregg Harper of Mississippi (Chair of House Administration Committee):

  • Date announced: Jan. 4
  • Terms: 5 terms
  • 2016 margin of victory: 36 points
  • 2016 presidential: Trump by 25 points

Bill Shuster of Pennsylvania (Chair of Transportation & Infrastructure Committee) :

  • Date announced: Jan. 2
  • Terms: 9 terms
  • 2016 margin of victory: 27 points
  • 2016 presidential: Trump by 43 points

Blake Farenthold of Texas:

  • Date announced: Dec. 14, 2017 (retiring in scandal)
  • Terms: 4 terms
  • 2016 margin of victory: 23 points
  • 2016 presidential: Trump by 24 points

Trent Franks of Arizona:

  • Date announced: Dec. 7, 2017 (resigned in scandal)
  • Terms: 7 full terms
  • 2016 margin of victory: 37 points
  • 2016 presidential: Trump by 21 points

Joe Barton of Texas:

  • Date announced: Nov. 30, 2017
  • Terms: 17
  • 2016 margin of victory: 19 points
  • 2016 presidential: Trump by 12 points

Bob Goodlatte of Virginia (Chair of Judiciary Committee):

  • Date announced: Nov. 9, 2017
  • Terms: 13
  • 2016 margin of victory: 34 points
  • 2016 presidential: Trump by 25 points

Ted Poe of Texas:

  • Date announced: Nov. 7, 2017
  • Terms: 7
  • 2016 margin of victory: 25 points
  • 2016 presidential: Trump by 9 points

Frank LoBiondo of New Jersey:

  • Date announced: Nov. 7, 2017
  • Terms: 12
  • 2016 margin of victory: 22 points
  • 2016 presidential: Trump by 5 points

Lamar Smith of Texas (Chair of Science, Space & Technology committee):

  • Date announced: Nov. 2, 2017
  • Terms: 15
  • 2016 margin of victory: 31 points
  • 2016 presidential: Trump by 10 points

Jeb Hensarling of Texas (Chair of Financial Services committee):

  • Date announced: Oct. 31, 2017
  • Terms: 8
  • 2016 margin of victory: 61 points
  • 2016 presidential: Trump by 28 points

Pat Tiberi of Ohio:

  • Date announced: Oct. 19, 2017
  • Terms: 9
  • 2016 margin of victory: 37 points
  • 2016 presidential: Trump by 11 points

Tim Murphy of Pennsylvania (resigned in scandal):

  • Date announced: Oct. 5, 2017
  • Terms: 7 full terms
  • 2016 margin of victory: uncontested
  • 2016 presidential: Trump by 20 points

Dave Trott of Michigan:

  • Date announced: Sept. 11, 2017
  • Terms: 2
  • 2016 margin of victory: 13 points
  • 2016 presidential: Trump by 5 points

Charlie Dent of Pennsylvania:

  • Date announced: Sept. 7, 2017
  • Terms: 7
  • 2016 margin of victory: 20 points
  • 2016 presidential: Trump by 8 points

Dave Reichert of Washington:

  • Date announced: Sept. 6, 2017
  • Terms: 7
  • 2016 margin of victory: 20 points
  • 2016 presidential: Clinton by 3 points

John J. Duncan Jr. of Tennessee:

  • Date announced: July 31, 2017
  • Terms: 15
  • 2016 margin of victory: 51 points
  • 2016 presidential: Trump by 35 points

Ileana Ros-Lehtinen of Florida:

  • Date announced: April 30, 2017
  • Terms: 14
  • 2016 margin of victory: 10 points
  • 2016 presidential: Clinton by 20 points

Lynn Jenkins of Kansas:

  • Date announced: Jan. 25, 2017
  • Terms: 5
  • 2016 margin of victory: 28 points
  • 2016 presidential: Trump by 19 points

Sam Johnson of Texas:

  • Date announced: Jan. 6, 2017
  • Terms: 13
  • 2016 margin of victory: 27 points
  • 2016 presidential: Trump by 14 points

Go deeper

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NATO Secretary-General Jens Stoltenberg. Photo: Dursun Aydemir/Anadolu Agency via Getty

The U.S. and NATO provided Russia with written proposals on Wednesday to advance a "diplomatic path forward," even as they warned that Russia could invade Ukraine within days.

Why it matters: This is a delicate diplomatic balancing act. The U.S. and NATO want to show they're serious about diplomacy but unwilling to compromise on "core principles" — all without providing Vladimir Putin with an additional pretext for escalation.

The political leanings of the Supreme Court justices

Data: Martin-Quinn scores; Chart: Axios Visuals

The Supreme Court will continue to have a solid conservative majority even with Justice Stephen Breyer's retirement.

How to read the chart: An analysis by political scientists Andrew Martin and Kevin Quinn, known as the Martin-Quinn Score, places judges on an ideological spectrum. A lower score indicates a more liberal justice, whereas a higher score indicates a more conservative justice.

The front-runners for Biden's Supreme Court pick

Judge Kentaji Brown Jackson (left) and Justice Leondra Kruger (right) Tom Williams-Pool/Getty Images and Lonnie Tague, US Department of Justice

Two highly accomplished Black female judges — Ketanji Brown Jackson, a judge on the D.C. Circuit Court of Appeals; and Leondra Kruger, a justice on the California Supreme Court — are seen as the early front-runners to replace retiring Supreme Court Justice Stephen Breyer.

The big picture: Jackson is a powerful federal judge with a record that progressives feel they can trust. Kruger was a highly regarded litigator and has carved out a reputation for working well with conservative judges.