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The experimental vaccine against the AIDS virus for the 2016 clinical trial. Photo: Mujahid Safodien/AFP via Getty Images

A vaccine aimed at preventing the human immunodeficiency virus (HIV) has failed and will end its clinical trial in South Africa early, according to the National Institute of Allergy and Infectious Diseases.

Why it matters: About 34 million people are living with HIV/AIDS globally, according to 2018 data from the World Health Organization. South Africa has one of the highest HIV rates in the world, with young women especially at risk.

"An HIV vaccine is essential to end the global pandemic, and we hoped this vaccine candidate would work. Regrettably, it does not. Research continues on other approaches to a safe and effective HIV vaccine, which I still believe can be achieved."
— Anthony Fauci, director of the NIAID, said in a written statement on Monday

Details: The trial, sponsored by NIAID, began in 2016 with 5,407 HIV-negative volunteers across South Africa and was supposed to end in July 2022.

  • 129 HIV infections occurred among the vaccine recipients, and 123 HIV infections occurred among the placebo recipients.
  • There is no evidence that the vaccine caused harm, NIAID said.
  • The Global HIV Vaccine Enterprise expressed "deep disappointment" in learning the trial was ending, according to a statement.

What's next: Two late-stage, multinational HIV vaccine trials are still being conducted by the National Institutes of Health.

Go deeper: HIV-positive babies could benefit from treatment days after birth

Go deeper

Momentum builds to ban lawmakers from trading stocks

Illustration: Sarah Grillo/Axios

Some progressive Democrats and MAGA Republicans are uniting on a proposal to ban sitting lawmakers from trading individual stocks, although it's unlikely that leadership will bring the bill up for a vote.

Why it matters: Members of Congress have great power to move stock prices, and great financial incentives to do so.

Thousands without power as "hazardous" winter storm lashes East Coast

Satellite imagery of the Northeastern U.S. taken by NOAA on Jan. 17. Photo: NOAA

A major winter storm was lashing much of the East Coast on Sunday, causing widespread power outages and disrupting travel over the holiday weekend.

The latest: The Weather Prediction Center said in a storm summary Monday that winter storm warnings are still in effect for portions of the Central Appalachians, Ohio Valley, interior Mid-Atlantic, and Northeast, while portions of the Central Appalachians and coastal New England are under high wind warnings.

Colleyville Rabbi credits survival to active-shooter training

Rabbi Charlie Cytron-Walker, one of the people taken hostage in a synagogue outside Fort Worth on Saturday, said in an interview with CBS Monday that he initially took in the man because he thought he needed shelter.

The big picture: Cytron-Walker said he spoke to the hostage taker, identified by the FBI as 44-year-old British national Malik Faisal Akram, for several minutes and made him tea before Akram took the rabbi and three other people hostage during Shabbat services for around 11 hours in Colleyville, Texas.