The big picture: Republicans Rick Scott and Ron DeSantis have never openly disagreed with Trump before. In fact, they've benefitted from his endorsements, and DeSantis even released an entire ad mirroring himself after Trump.

• That doesn't mean they don't genuinely disagree with him now, but they're both in tough races and will rely on a new electorate, shaped by Hurricane Maria, to get elected — not on President Trump.

Battle lines: Gov. Rick Scott, who's running for Senate, tweeted: "I disagree with @POTUS– an independent study said thousands were lost and Gov. Rosselló agreed. I've been to Puerto Rico 7 times & saw devastation firsthand. The loss of any life is tragic."

• A spokesperson for Rep. Ron DeSantis, who's running for governor, told NBC's Ali Vitali that DeSantis "doesn’t believe any loss of life has been inflated," as POTUS claimed.
• Democratic Sen. Bill Nelson, who's facing a tough re-election race against Scott, tweeted: "The president’s comments on the nearly 3,000 American lives lost in Puerto Rico are shameful. We deserve and expect more from someone who holds the highest office in our country."

Go deeper: Politicians trash Trump's Hurricane Maria tweet