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Dina Powell at the White House. Photo: Andrew Harnik / AP

Dr. Nadia Schadlow, who currently works on strategy on the staff of National Security Adviser H.R. McMaster, is the likely successor to Dina Powell, deputy national security adviser for strategy. Powell announced Friday that she will leave the White House early next year — the first in an expected wave of senior West Wing departures.

Why it matters: Powell was one of the few senior West Wing officials with previous White House experience, and the coming brain drain could leave President Trump with key holes. The administration has always been thinly staffed, and bringing top people in will be hard, in part because of uncertainty surrounding the Mueller investigation.

Why she's leaving: Powell told me she had committed to one year of service, and her family remained in New York.

Defense Secretary James Mattis said in a statement: "With the pending departure of Dina Powell, we are losing an invaluable member of the President's national security team. I personally appreciate Dina's partnership and contributions to the mission of the Department of Defense."

Why she matters: Powell was among the aides who communicated well with Trump, and accompanied him on all his overseas trips. She helped with White House efforts on a restart of Middle East policy.

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Go deeper

Kate Marino, author of Markets
52 mins ago - Economy & Business

Omicron outbreaks were bad for business in January

Data: New York Federal Reserve Bank; Chart: Axios Visuals

Emerging anecdotal evidence shows just how hard the recent rise in COVID-19 cases hit businesses in early January — but that hasn't hurt some business leaders’ longer-term views on their companies' prospects.

Why it matters: Increasingly, the economic recovery has come in fits and starts that move in tandem with new peaks in cases. Look no further than the thousands of cancelled flights and shuttered Broadway theaters in the wake of the Omicron variant's spread over the last few months.

Tina Reed, author of Vitals
1 hour ago - Health

The shifting definition of fully vaccinated

Illustration: Sarah Grillo/Axios

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Why it matters: CDC officials have been balancing the job of convincing Americans who've already gotten two doses of the importance of boosters with getting many Americans who still need their first doses to get their shots at all.

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2 hours ago - Economy & Business

Small businesses see hiring as No. 1 worry

Illustration: Aïda Amer/Axios

Almost every small business owner in a Goldman Sachs survey is having trouble hiring — and two-thirds think the federal government has done too little to ease their hiring, supply-chain and inflation worries.

Why it matters: The Goldman Sachs research gives a vivid window into the continuing headwinds and hardship for entrepreneurs.