Sign up for our daily briefing

Make your busy days simpler with the Axios AM and PM newsletters. Catch up on what's new and why it matters in just 5 minutes.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on the day's biggest business stories

Subscribe to the Axios Closer newsletter for insights into the day’s business news and trends and why they matter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios Pro Rata

Dive into the world of dealmakers across VC, PE and M&A with Axios Pro Rata. Delivered daily to your inbox by Dan Primack and Kia Kokalitcheva.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sports news worthy of your time

Binge on the stats and stories that drive the sports world with the Axios Sports newsletter. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Tech news worthy of your time

Get our smart take on technology from the Valley and D.C. with Axios Login. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Get the inside stories

Get an insider's guide to the new White House with Axios Sneak Peek. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Denver news?

Get a daily digest of the most important stories affecting your hometown with Axios Denver

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Des Moines news?

Get a daily digest of the most important stories affecting your hometown with the Axios Des Moines newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Twin Cities news?

Get a daily digest of the most important stories affecting your hometown with Axios Twin Cities

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Tampa Bay news?

Get a daily digest of the most important stories affecting your hometown with the Axios Tampa Bay newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Charlotte news?

Get a daily digest of the most important stories affecting your hometown with Axios Charlotte

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Nashville news?

Get a daily digest of the most important stories affecting your hometown with the Axios Nashville newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Columbus news?

Get a daily digest of the most important stories affecting your hometown with the Axios Columbus newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Dallas news?

Get a daily digest of the most important stories affecting your hometown with the Axios Dallas newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Austin news?

Get a daily digest of the most important stories affecting your hometown with the Axios Austin newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Atlanta news?

Get a daily digest of the most important stories affecting your hometown with the Axios Atlanta newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Philadelphia news?

Get a daily digest of the most important stories affecting your hometown with the Axios Philadelphia newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Chicago news?

Get a daily digest of the most important stories affecting your hometown with the Axios Chicago newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios NW Arkansas

Stay up-to-date on the most important and interesting stories affecting NW Arkansas, authored by local reporters

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top DC news?

Get a daily digest of the most important stories affecting your hometown with the Axios DC newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!
Expand chart
Data: DRC Ministry of Health; Chart: Andrew Witherspoon, Harry Stevens/Axios

The Ebola vaccine — which appears to have an effectiveness of more than 97% when given 10 days before infection — also must be given quickly once an outbreak starts, according to scientists in a study out this week.

Why it matters: One of the few bright spots about this deadly outbreak in the Democratic Republic of the Congo is the preliminary finding that the rVSV-ZEBOV vaccine is very effective. But the violent disruptions of the hard efforts of public health officials there — causing the WHO chief to warn, "The world has never seen anything like this" — are endangering that benefit.

What they did: The research team from the University of Florida used a spatial model examining human mobility, poverty and population density to see how this impacted the effectiveness of the vaccination program during the prior Ebola outbreak in the DRC in 2018.

  • "Our primary purpose was to investigate the timing and pattern of geographical spread of an Ebola outbreak starting from initial cases," study author Burton Singer tells Axios.
  • They used Merck's rVSV-ZEBOV vaccine, as it was the most effective known vaccine and it was available for distribution, Singer says.
  • The outbreak in May 2018 was in a different location than the current outbreak.

What they found: The vaccination program lessened both the geographical area that was at risk and the risk level for infection within that region, the study found.

  • The vaccination program contracted the geographical area at risk for Ebola by up to 70%.
  • The program reduced the level of risk within that region by up to 70%.

Yes, but: It also shows there may be a significant drop in its ability to lower infection rates in an area if it's given even a week after the infection has started. A delay of a week led to the above effects to drop to 33% and 45%, respectively, the authors say.

  • "I was surprised by the dramatic potential impact across a substantial geographical area of a delay of even one week in initiating vaccinations following an outbreak. Vaccinating people as early as possible is critically important," Singer says.

What's happening now: Unfortunately, the vaccination regime is being stymied in the current outbreak by community distrust and violent attacks, including the recent death of a WHO epidemiologist Richard Mouzoko.

"I’m profoundly worried, because the number of cases increases with the frequency of attacks. They are almost every day. It disrupts our operations, and when operations are disrupted, the virus gets a free ride."
"After Richard was killed, we were operating at very low levels for three days. And if we can’t find cases as soon as possible, and if we aren’t able to vaccinate everyone, there is a build-up of the chances of this spreading to other provinces and neighbouring countries. That chance gets higher and higher."
— WHO chief Tedros Adhanom Ghebreyesus, in Q&A published in Nature

By the numbers: DRC says they've vaccinated 109,844 people since they began vaccinating people on Aug. 8.

  • The only vaccine used so far in this epidemic is Merck's rVSV-ZEBOV vaccine.
  • Beth-Ann Coller, executive director of project management and leadership at Merck, tells Axios the company was glad the preliminary data shows a "robust response" to the vaccine, of which the company had agreed to stockpile 300,000 doses as a donation to the WHO.
  • Because it takes roughly one year to produce these vaccines, Coller says, they are already working to replenish their stocks.
  • Merck is moving to have the vaccine licensed in the U.S. and the EU, she adds.
  • WHO spokesperson Tarik Jasarevic says WHO also has used the vaccine for nearly 5,000 health and frontline workers in Uganda, 1,400 in South Sudan, and just started vaccinations in the town of Gisenyi, Rwanda.

Meanwhile, Ghebreyesus called for more funding from the international community, saying, "We have just 50% of what we need."

  • The Paul G. Allen Family Foundation announced yesterday roughly $2.4 million via its Ebola Response Accelerator Challenge to 3 winners, including the WHO, to focus on the community engagement needed to help make the region safer for treatment and vaccination regimes for this Ebola outbreak.

Go deeper:

Go deeper

45 million Americans under winter storm watches near New England

Computer model projection showing the winds moving around the powerful East Coast storm on Saturday Jan. 29, 2022. Credit: https://earth.nullschool.net

Nearly 45 million Americans are under winter weather alerts and warnings from North Carolina to northeastern Maine Thursday night, as a major winter storm threatens the region.

Why it matters: It is predicted to be the biggest blizzard since 2018 to strike the Northeast with more than 2 feet of snow possible in parts of eastern Massachusetts, according to the National Weather Service.

1 hour ago - World

Zelensky questions U.S. warnings of "imminent" invasion in Biden call

Biden and Zelensky at the White House last October. Photo: Brendan Smialowski/AFP via Getty

President Biden and Ukrainian President Volodymyr Zelensky had a back-and-forth in their call this evening about just how "imminent" the threat of a Russian invasion might be, according to three sources briefed on the call.

Why it matters: Biden has said previously that he believes Russian President Vladimir Putin will probably "move in" to Ukraine, and White House press secretary Jen Psaki said Thursday afternoon that "an invasion could come at any time."

Democrats stiff Biden as poll numbers hit low point

Photo illustration: Aïda Amer/Axios. Photo: Christopher Furlong/Getty Images

Democrats in swing states and vulnerable districts in this year's pivotal midterms are distancing themselves from President Biden on social media as his poll numbers hit their lowest point.

Why it matters: The digital distance is one sign of the concern candidates feel about a person they'd normally embrace. Incumbent presidents — including one who believes he needs to come to their hometowns to sell his message — would normally be political gold for candidates from the same party.