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Photo: House of Commons/PA Images via Getty Images

U.K. Prime Minister Theresa May saw her maligned Brexit deal hit with a third defeat in the House of Commons on Friday in a 344-286 vote.

Why it matters: It means that big changes may be coming to the British political sphere over the next few days, like the announcement of an early general election, as only way that the EU might grant another long-term extension — the U.K. is currently set to leave the bloc on April 12 — would be through some form of significant political upheaval. Otherwise, the U.K. would be forced into a no-deal Brexit.

The state of play: This vote was a little different than the last two. It split the deal's two components — the withdrawal agreement, a legal document setting out the terms of Brexit, and the political declaration, a roadmap for the future EU-U.K. relationship — for a vote only on the withdrawal agreement.

  • Had the vote been successful, it would have lengthened the EU's Brexit extension from April 12 to May 22, giving the U.K. more breathing room before leaving to avoid having to take part in European elections on May 23.

Go deeper: The Brexit Day that wasn't

Go deeper

Scoop: Hundreds of Biden staffers receive COVID vaccine

Screenshots of an email inviting White House staff to receive the COVID-19 vaccine, obtained by Alayna Treene/Axios

A week into the job, President Biden's White House medical team has administered the coronavirus vaccine to several hundred staffers — and aims to vaccinate all in-person staff over the next few weeks, officials tell Axios.

Why it matters: The new administration is ramping up steps to protect President Biden and all staff working inside the White House complex. The administration is also requiring daily employee COVID tests and N95 masks at all times.

Dan Primack, author of Pro Rata
47 mins ago - Economy & Business

The Leon Black clock strikes midnight

Illustration: Sarah Grillo/Axios

Leon Black is "retiring" as CEO of Apollo Global Management, the alternative investment giant he has led since co-founding it in 1990. But he is not making a full break, as Black will remain chair of Apollo's board of directors.

Why it matters: This is the culmination of 18 months of head-in-the-sand obfuscation of Black's dealings with Jeffrey Epstein.

Reddit traders look to pummel Wall Street's old guard

Illustration: Sarah Grillo/Axios

Reddit traders are taking on Wall Street pros at their own game with this basic mantra: Stocks will always go up.

Why it matters: Their trades — egged on in Reddit threads — have played a role in historic market activity in recent days.