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Palestinians in the Gaza Strip leave their neighborhood on Wednesday following an explosion. Photo: li Jadallah/Anadolu Agency via Getty Images

Tel Aviv — With Israel and Hamas now engaged in their most destructive fight in seven years, the Biden administration is dispatching a State Department official to join the de-escalation efforts.

The latest: The Israeli air force attacked a meeting of senior Hamas military leaders on Wednesday in Gaza and reported it had killed the Gaza City Brigade commander and the heads of Hamas’ cyber arm and weapons research and development department, along with at least three other senior officials.

The fighting intensified overnight, with Hamas and other militants firing over 100 rockets toward Tel Aviv and other nearby cities, and Israel continuing its air campaign in the Gaza Strip by destroying high-rise buildings, Hamas facilities and rocket units.

  • At least 53 Palestinians have been killed since the fighting began, including at least 14 children, according to the Gaza Ministry of Health.
  • Six Israelis have been killed and 200 wounded. The first Israeli soldier was killed and two others were critically wounded when Hamas fired anti-tank rockets at military vehicles along the border with Gaza.

What they're saying: "Israel is not preparing for a ceasefire. There is currently no end date for the operation. Only when we achieve complete quiet can we talk about calm. We will not listen to moral preaching against our duty to protect the citizens of Israel," said Israeli defense minister Benny Gantz.

  • Secretary of State Anthony Blinken said at a briefing on Wednesday: "There is a very clear and absolute distinction between a terrorist organization Hamas that is indiscriminately raining down rockets — in fact, targeting civilians — and Israel's response defending itself, that is targeting the terrorists who are raining down rockets on Israel.
  • Blinken added that Israel "has an extra burden in trying to do everything it possibly can to avoid civilian casualties even as it responds."

Behind the scenes: The Biden administration is trying to work with Egypt to push for de-escalation, U.S. and Israeli officials told me.

  • As Axios reported Wednesday morning, deputy assistant secretary of state for Israeli-Palestinian affairs Hady Amr will travel to Tel Aviv on Wednesday. Secretary of State Tony Blinken confirmed that news later on Wednesday.
  • That will be the most active U.S. intervention so far in the Gaza crisis, and Amr’s first trip to the region since assuming office.

Meanwhile, national security adviser Jake Sullivan spoke on Tuesday to his Egyptian counterpart, Abbas Kamel. The White House said Sullivan discussed “steps to restore calm over the coming days" with Egyptian officials.

  • State Department officials have also been communicating with Cairo.
  • Sullivan also spoke with his Israeli counterpart, Meir Ben-Shabbat. According to the White House, Sullivan condemned the Hamas rocket attacks and “conveyed the President’s unwavering support for Israel’s security and for its legitimate right to defend itself and its people, while protecting civilians."
  • Secretary of State Blinken also spoke on Tuesday with Israeli Foreign Minister Gabi Ashkenazi. Israeli officials tell me Blinken didn’t press the Israelis to stop the operation in Gaza for now, but he stressed the U.S. doesn’t want things to escalate into an all-out war and wants to prevent civilian casualties in Gaza.

The big picture: The Israeli-Palestinian conflict had been a low priority in President Biden's early months, but once a crisis erupted, the administration found itself understaffed.

  • Unlike his predecessors, Biden didn’t appoint an envoy for the Israeli-Palestinian issue. He still hasn't nominated an ambassador to Israel or followed through on his plans to reopen the U.S. consulate in Jerusalem.
  • That has left him without a senior diplomat on the ground to talk to either the Palestinian or Israeli leadership. At this time four years ago, Trump’s ambassador was already in Israel.
  • Instead, Amr has functioned as both the deputy assistant secretary and the de facto consul general and point of contact to the Palestinians.

The state of play: Egyptian and UN mediators are talking to both parties, but were rebuffed by the Israeli government when they raised the possibility of a ceasefire, Israeli officials tell me."

"We’re escalating towards a full-scale war. Leaders on all sides have to take the responsibility of de-escalation. The cost of war in Gaza is devastating. Stop the violence now."
UN envoy Tor Wennesland on Tuesday

This story was updated with new details about the latest air strikes.

Go deeper

May 11, 2021 - World

Explosions in Tel Aviv and Gaza as Israeli-Palestinian crisis escalates

Israel's Iron Dome aerial defense system intercepts a rocket fired from Gaza over southern Israel. Photo: Menahem Kahana/AFP via Getty

Tel Aviv — The Hamas and Islamic Jihad militant groups fired dozens of rockets from the Gaza Strip toward Tel Aviv and other cities in central Israel on Tuesday night, a new step in the current conflict that is likely to be followed by increased Israeli air strikes in Gaza.

Why it matters: The current crisis began in Jerusalem but has evolved into a military conflict across Israel and Gaza that remains on a path of escalation.

Updated May 14, 2021 - World

Death toll mounts as fighting between Israel and Hamas intensifies

Palestinian Muslims exchange wishes for Eid al-Fitr, marking the end of the holy month of Ramadan, near a razed building in the northern Gaza Strip town of Beit Lahia, on May 13. Photo: Majdi Fathi/NurPhoto via Getty Images

At least 109 Palestinians and seven people in Israel have been killed since recent fighting between Israel's military and Hamas began Monday.

The big picture: Israel began massing troops on its border with Gaza on Thursday, launching attacks from the air and ground as Hamas continued to fire rockets into Israel.

May 12, 2021 - World

Jerusalem crisis widens rift between Jewish and Arab Israelis

A rabbi inside a torched religious school in Lod. Photo: Ahmad Gharabli/AFP via Getty

The crisis in Jerusalem and Gaza is fueling hostility and fear between Jewish and Arab citizens of Israel.

Why it matters: This week has seen the worst inter-communal violence in Israel since the start of the Second Intifada in 2000.