Dexamethasone is creating cautious optimism
The new best hope for treating seriously ill coronavirus patients may come from a synthetic steroid that has been around for roughly 60 years.
Why it matters: Because it's an old, inexpensive drug, dexamethasone may have a leg up on remdesivir and other new, potentially costly treatments — especially if they don't work as well.
Driving the news: British researchers said yesterday that dexamethasone helped save seriously ill coronavirus patients' lives in a randomized, controlled trial.
- The steroid significantly reduced the risk of death among patients who were on a ventilator, and showed more limited benefit for patients who were on supplemental oxygen, according to the researchers' press release. It showed no benefit for mild cases.
Between the lines: Some physicians and researchers, including Peter Bach of Memorial Sloan Kettering, say dexamethasone now seems more promising than remdesivir — the only other drug that has been shown to help treat coronavirus.
- Dexamethasone appears to save lives, and is most effective with severe cases. Remdesivir only shortens hospitalizations and is most effective for less severe cases.
- Dexamethasone also is available as an oral tablet, whereas remdesivir is an IV medication.
- And dexamethasone only costs about 50 cents per tablet, according to drug pricing research firm 46brooklyn, while Wall Street analysts believe Gilead may put a $5,000 price tag on each course of remdesivir.
Yes, but: Yesterday's encouraging news was another example of what Politico described as "science by press release" — a persistent problem during this pandemic.
- Many researchers said it's difficult to call dexamethasone a winner yet, given the amount of misinformation and retractions that have come out with other coronavirus treatments.
- The British researchers said they are "working to publish the full details as soon as possible."