Doctors look at a patient with spinal muscular atrophy. Photo: Lola Bou/Anadolu Agency/Getty Images

Novartis bought biotech company AveXis for $8.7 billion earlier this year, and executives are thinking about charging at least $4 million for AveXis' highly touted gene therapy to treat spinal muscular atrophy, according to Endpoints News.

Why it matters: This would be the most expensive drug in the world, by far, if it gets FDA approval, and it would raise drug pricing concerns to a new level. As Walid Gellad, a medical professor at the University of Pittsburgh who studies pharmaceuticals, mused today: "The fact that we can spread a price across thousands or millions of people does not justify a given price."

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Amy Harder, author of Generate
2 hours ago - Energy & Environment

Climate change goes mainstream in presidential debate

Photo illustration: Aïda Amer/Axios. Photo: Olivier Douliery-Pool/Getty

The most notable part of Thursday’s presidential debate on climate change was the fact it was included as a topic and assumed as a fact.

The big picture: This is the first time in U.S. presidential history that climate change was a featured issue at a debate. It signals how the problem has become part of the fabric of our society. More extreme weather, like the wildfires ravaging Colorado, is pushing the topic to the front-burner.

Finally, a real debate

Photo: Morry Gash/AP

A more disciplined President Trump held back from the rowdy interruptions at tonight's debate in Nashville, while making some assertions so outlandish that Joe Biden chuckled and even closed his eyes. A Trump campaign adviser told Axios: "He finally listened." 

The result: A real debate.

Biden to Trump: "I have not taken a penny from any foreign source ever in my life"

Former VP Joe Biden pushed back Thursday against allegations from President Trump, saying he had never profited from foreign sources. "Nothing was unethical," Biden told debate moderator Kristen Welker about his son Hunter's work in Ukraine while he was vice president.

Why it matters: Earlier on Thursday, Hunter Biden's former business partner, Tony Bobulinski, released a statement saying Joe Biden's claims that he never discussed overseas business dealings with his son were "false."