Sign up for our daily briefing

Make your busy days simpler with Axios AM/PM. Catch up on what's new and why it matters in just 5 minutes.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on the day's biggest business stories

Subscribe to Axios Closer for insights into the day’s business news and trends and why they matter

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios Pro Rata

Dive into the world of dealmakers across VC, PE and M&A with Axios Pro Rata. Delivered daily to your inbox by Dan Primack and Kia Kokalitcheva.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sports news worthy of your time

Binge on the stats and stories that drive the sports world with Axios Sports. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Tech news worthy of your time

Get our smart take on technology from the Valley and D.C. with Axios Login. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Get the inside stories

Get an insider's guide to the new White House with Axios Sneak Peek. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Denver news?

Get a daily digest of the most important stories affecting your hometown with Axios Denver

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Des Moines news?

Get a daily digest of the most important stories affecting your hometown with Axios Des Moines

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Twin Cities news?

Get a daily digest of the most important stories affecting your hometown with Axios Twin Cities

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Tampa Bay news?

Get a daily digest of the most important stories affecting your hometown with Axios Tampa Bay

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Charlotte news?

Get a daily digest of the most important stories affecting your hometown with Axios Charlotte

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Nashville news?

Get a daily digest of the most important stories affecting your hometown with the Axios Nashville newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Columbus news?

Get a daily digest of the most important stories affecting your hometown with the Axios Columbus newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Dallas news?

Get a daily digest of the most important stories affecting your hometown with the Axios Dallas newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Austin news?

Get a daily digest of the most important stories affecting your hometown with the Axios Austin newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Atlanta news?

Get a daily digest of the most important stories affecting your hometown with the Axios Atlanta newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Philadelphia news?

Get a daily digest of the most important stories affecting your hometown with the Axios Philadelphia newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Chicago news?

Get a daily digest of the most important stories affecting your hometown with the Axios Chicago newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios NW Arkansas

Stay up-to-date on the most important and interesting stories affecting NW Arkansas, authored by local reporters

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top DC news?

Get a daily digest of the most important stories affecting your hometown with the Axios DC newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Illustration: Eniola Odetunde/Axios

Pfizer's new COVID-19 antiviral is highly effective when given early in the course of an infection — underscoring the importance of cheap, easily accessible COVID-19 tests, including at-home rapid versions.

Driving the news: Pfizer's oral antiviral drug reduced the risk of hospitalization or death from COVID-19 by 89%, according to interim results from a mid-to-late-stage study announced by the company on Friday, my colleague Rebecca Falconer writes.

  • Notably, that protection came when treatment began within three days of developing symptoms.
  • Other treatments have shown success in preventing death among hospitalized COVID patients, but Pfizer's pill keeps them out of the hospital altogether — provided it's given in time.

The big picture: Getting the most out of treatments like Pfizer's will require ensuring that people can easily and regularly get tested — or test themselves — for COVID-19.

  • The catch: More than 18 months into the pandemic, the U.S. is still struggling to manage testing — both lab-based PCR tests and rapid, at-home diagnostics.

Between the lines: An investigative piece published by ProPublica this week outlined the regulatory failures and lack of public support that delayed at-home tests in the U.S. for months and have kept them expensive and hard to find since.

  • The U.K., by contrast, provides up to seven free at-home tests for people who can't get tests at work or home, while Germany long provided such tests free of charge.
  • While the Biden administration has invested billions to expand the supply of rapid tests, diagnostics are still limited and costly, and vaccine mandates — which often include a regular screening option — will further stress supplies.

What's next: Making rapid, at-home diagnostics for diseases more available could provide benefits that go beyond COVID-19.

  • Tamiflu, for instance, can reduce the severity of a flu infection, but it works most effectively if taken shortly after symptoms commence — symptoms that often resemble those of other respiratory illnesses.
  • At-home flu tests could make that possible.

Go deeper

Judge temporarily blocks Biden vaccine mandate for federal contractors

Photo: Chip Somodevilla via Getty Images

A federal judge on Tuesday temporarily blocked President Biden's vaccine mandate for federal contractors nationwide.

Why it matters: It's the latest setback in the Biden administration's rollout of COVID-19 vaccine requirements. Federal judges in two states temporarily barred the administration from enforcing mandates for millions of workers last week.

23 hours ago - Health

Report: COVID exacerbated young people's "unprecedented" mental health challenges

Surgeon General Dr. Vivek H. Murthy speaks during a press briefing in the Brady Briefing Room of the White House in Washington, D.C. on July 15. Photo: Saul Loeb/AFP via Getty Images

The U.S. surgeon general warned on Tuesday young people face "unprecedented" mental health challenges — and the pandemic has only made matters worse.

Why it matters: Depression, suicidal ideation and emergency room visits for mental health reasons have risen significantly in young people, according to the 53-page advisory from the country's top physician, Dr. Vivek H. Murthy.

COVID "paradigm shift" coming for Tennessee

Tennessee health commissioner Lisa Piercey speaking in 2020 as Gov. Bill Lee watches. Photo: Mark Humphrey/AP

Tennessee health commissioner Lisa Piercey expects the state to start receiving new COVID-fighting pills in the coming weeks.

  • Piercey predicts this will trigger a "paradigm shift" in the pandemic, with a renewed emphasis on quickly identifying COVID-19 infections.