May 31, 2017

NIH announces new push on opioids

Associated Press

The National Institutes of Health on Wednesday announced a joint initiative with pharmaceutical companies to spur the development of drugs to address the opioid epidemic. It will start with a series of private workshops over the next six weeks and focus on three areas:

  • Developing interventions for reversing overdoses, including stronger, longer-lasting medicines to counteract synthetic opioids and, in the long-term, potentially wearable devices that sense an overdose and automatically inject naloxone.
  • New treatments for opioid addiction. The NIH is investigating new medications, beyond the three currently available, repurposing and reformulating approved drugs (like lorcaserin), and even vaccines that would spur the production of antibodies against opioids and prevent them from entering the brain.
  • Non-addictive treatments for chronic pain. The NIH plans to target two separate pain-signaling pathways in hopes of developing an alternative to synthetic opioid medications. They are also researching compounds that target other opioid receptors and ways to formulate drugs so they can't be snorted or injected.

Go deeper

The growing coronavirus recession threat

Illustration: Aïda Amer/Axios

In just a matter of weeks, top economists and investment bank analysts have gone from expecting the coronavirus outbreak to have minimal impact on the U.S. economy to warning that an outright recession may be on the horizon.

What's happening: The spread of confirmed coronavirus cases in Europe, the Middle East and the U.S., and the speed at which they are being discovered has set the table for the outbreak to have a larger and much costlier impact.

Mass shooting in Milwaukee: What we know

Milwaukee Mayor Tom Barrett in 2012. Photo: John Gress/Corbis via Getty Images

Six people died in a shooting at the Molson Coors Brewing Company in Milwaukee on Wednesday, including the gunman, Mayor Tom Barrett told reporters at a Wednesday evening press conference with local police.

Details: All of the victims worked at the brewery complex, as did the shooter who died of "an apparent self-inflicted gunshot wound," police confirmed in a statement late Wednesday.

Go deeperArrowUpdated 8 hours ago - Politics & Policy

Coronavirus updates: South Korea case count tops 2,000

Data: The Center for Systems Science and Engineering at Johns Hopkins, the CDC, and China's Health Ministry. Note: China numbers are for the mainland only and U.S. numbers include repatriated citizens.

33 people in California have tested positive for the coronavirus, and health officials are monitoring 8,400 people who have recently returned from "points of concern," Gov. Gavin Newsom said Thursday.

The big picture: COVID-19 has killed more than 2,850 people and infected over 83,000 others in some 50 countries and territories. The novel coronavirus is now affecting every continent but Antarctica, and the WHO said Wednesday the number of new cases reported outside China has exceeded those inside the country for the first time.

Go deeperArrowUpdated 8 hours ago - Health