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Two mice reach for a pinpoint object after receiving a therapeutic drug post-stroke. Photo: H. Abe et al., Science (2018)
A new drug compound can successfully speed up rehabilitation for animals recovering from a stroke, according to research published in Science Thursday. If it works in humans, it could eventually extend the time for repairing some brain functions after stroke, Eileen Drage O'Reilly reports.
The big picture: An estimated 1.7 million people suffer a traumatic brain injury in the U.S. every year and almost 800,000 of those are from a stroke. Strokes kill 140,000 people a year and are the leading cause of serious long-term disability, CDC says.
Timing is key: "We believe there is a 'window of time' (about 3 months) for plasticity to allow motor recovery," Argye Elizabeth Hillis, neurology professor at Johns Hopkins University School of Medicine who was not part of the study, tells Axios.
"People currently recover to varying degrees, but stroke remains one of the most common causes of disability in adults," Hillis says.
The overall chances of dying from an infectious disease are decreasing in the U.S., but the probability can vary greatly from county to county, according to data recently published in the Journal of the American Medical Association.
The bottom line: Overall death rates dropped between 1980 and 2014 for HIV/AIDS, tuberculosis and other infectious diseases. But from 2000 to 2014, deaths from diarrhea-related diseases increased in the U.S. That may be largely because of bacteria that has become resistant to antibiotics.
"We want people at the local level to take this information and use it to make decisions, and not to be fooled by state average numbers."— Charbel el Bcheraoui, assistant professor at the University of Washington
A bowhead whale surfaces among ice floes in Fram Strait. Photo: Kit M. Kovacs and Christian Lydersen/Norwegian Polar Institute
Whether winter or summer, bowhead whales stick to the Arctic Ocean. Beneath the ice, in frigid waters and 24-hour darkness for months, the intimate details of their 200-year-long lives are practically off-limits for scientists — and largely unknown.
From 2010–2014, the University of Washington's Kate Stafford and her colleagues at the Norwegian Polar Institute collected data using underwater microphones in the North Atlantic's Fram Strait, where one of the Arctic's four populations of bowhead whales resides.
"From November to early April, the whales were screaming their heads off under the ice. It was super unexpected and super cool," Stafford says.
Unlike humpback whales that collectively sing more or less the same song over a season, the repertoire for bowheads is more vast and diverse: the researchers found the population of about 300 whales sang 184 distinct songs over the three years. Some were sung for a few hours or days but rarely ever more than a month. Over the winter breeding season, the whales sang multiple different songs. The following year, they changed it up altogether.
“Bowhead whales are completely different. And I have no idea why,” Stafford says.
What it sounds like: Each song lasts 45 seconds to 2 minutes but can be repeated to make a long bout of singing, Stafford says. Their frequency ranges from 50 Hz up to 5000 Hz. "They scream, cry, whine, purr, moan, shout."
The unknown: Without visually studying the whales as they sing, Stafford says it's unknown whether individual animals are producing different songs, whether they are sung exclusively by males and for what purpose (for instance, scientists assume that, like in humpbacks, it is related to mating), or why they change songs.
Go deeper: Read Krista Langlois' piece in Hakai on the relationship between whales and indigenous people.