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Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

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Illustration: Sarah Grillo/Axios

The first U.S. clinical trial for a novel coronavirus vaccine began yesterday, based on a formulation selected by Moderna Therapeutics and the National Institute of Allergy and Infectious Diseases (NIAID).

Between the lines: Moderna was the first biotech unicorn, valued by venture capitalists at $3 billion in early 2015, before later going public in the largest-ever IPO for a development-stage biotech. We wanted flying cars, but instead we maybe got a civilization-saver.

Moderna wasn't just a VC-backed startup. It was a VC-created startup, inside an incubator program run by Cambridge, Mass.-based Flagship Pioneering. It didn't even have a name for the initial nine months of its life, just a project number.

Here's the basic concept, as I wrote in 2015 for Fortune:

Moderna’s core technology is designed to help people make medicines within their own cells, rather than create something in a lab which patients need to ingest or inject (i.e., the way other biotech works). It does so by injecting messenger RNA into the body, and then that mRNA stimulates the person’s cells to create the needed therapeutic proteins. Patient, heal thyself. Equally important, Moderna claims that its mRNA design is able to evade the typical human immune response that has felled past mRNA efforts.
Not only does this open up a massive number of therapeutic possibilities, but it also could make Moderna’s products significantly faster to test and cheaper to buy. Namely because it can use common mRNA manufacturing facilities and processes to create the mRNA that can be used for all sorts of indications, rather than having to create discrete ones for each new candidate (as is typically done today).

Noubar Afeyan, Flagship's founder and a Moderna board member, tells me that the "faster to test" part is a big reason why the company was able to already push its vaccine into Phase 1 clinical trials. He also believes that, if proven safe and effective, it could hit market sooner than would other, more traditionally developed vaccines (even after adjusting for government fast-tracking).

  • Caveat: Moderna hopes that the trials, which are being run by the NIH, could reach Phase 3 by the fall. If all endpoints are met, that could mean a vaccine by this time next year.

Moderna had been collaborating for several years with NIAID on developing coronavirus vaccines, and even had been preparing for a 2020 "pandemic test" whereby it would see how quickly it could design, develop, and mass manufacture a global vaccine.

All of that changed in early January, when Chinese authorities disclosed the genetic code for this new coronavirus.

  • Moderna refocused all of its coronavirus work toward COVID-19, with CEO Stéphane Bancel telling Axios: "Everything else would be a disruption and waste of time."
  • Within just a few days, Moderna had designed a vaccine on its computers, without access to the virus itself.

The bottom line: Moderna is not the only company working on a vaccine. Just today came reports that Pfizer is in talks with Germany's BioNTech about a joint development deal, and some biotechs are testing vaccines previously developed and approved for other diseases (including alt coronavirus strains). But Moderna's candidate is the first to clinical trials, and serves as a reminder that not all unicorns were founded to help millennials do errands their moms used to do for them.

Go deeper: Coronavirus vaccines in development aren't a short-term cure

Go deeper

Surprising pandemic side effect: Soaring trade deficits

Source: Census Bureau and Bureau of Economic Analysis; Chart: Axios Visuals

Inflation and jobs may get all the economic headlines, but meanwhile a big shift is taking place in the underpinnings of the world economy: The U.S. trade deficit is soaring.

What's happening: Americans' spending on imported physical goods has gone through the roof, while exports are growing slowly, making the U.S. the world's consumer of last resort.

Mike Allen, author of AM
1 hour ago - Politics & Policy

Third Way: "Big Lie" could become "Big Coup"

Graphic: Third Way

Third Way, the center-left think tank, is urging fellow Democrats to respond to the Capitol riot with "the size, scope, and seriousness of a presidential campaign," co-founder Matt Bennett tells me.

Driving the news: "For the first time in U.S. history, a party must mount two parallel presidential campaigns: one to win the election, and the other to prevent its theft," Bennett said, calling this "a Paul Revere moment."

Advocates say Biden has let Haitian migrants down

Photo illustration: Aïda Amer/Axios. Photos: Chip Somodevilla/Getty Images, Christian Torres/Anadolu Agency via Getty Images

Continued turmoil in Haiti is causing a growing number of Haitians to try to make it to American shores — and some advocates say the Biden administration isn't supporting this community in its time of crisis.

The big picture: Haitian-American activists in South Florida told Axios Today they feel like President Biden has gone back on campaign promises he made to the community to stand up for them.