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Illustration: Rebecca Zisser/Axios

One reason that major cities are able to attract the most talent is that they have wide variety of work options — and that means a variety of working space options from traditional offices to startup-friendly co-working venues.

The big picture: Not so long ago, it was a big deal for a co-working space to open up in smaller or "second-tier" cities because it signaled there was finally enough demand from newcomers looking for a cool place to work.

  • Now the focus is to create bigger, branded, physical places to attract more companies, entrepreneurs and investment, according to a new "Rise of the Rest Ecosystem Playbook" put out by Revolution.
  • Between the lines: These developments are using the "if you build it, they will come" strategy, hoping to lure people wanting to escape the high prices of the usual hot spots.

The playbook breaks down four archetypes that are being built across the 43 cities that Steve Case and Revolution have visited during Rise of the Rest tours over the past 5 years.

"[E]very city, without fail, is trying to figure out how to retain the talent they have, encourage people who have left to return, and recruit new people to consider moving there," Case emailed.

1. Anchor Tenant: A key company that attracts others to cluster around it (like in a mall).

  • Detroit: Quicken Loans moved it's headquarters from the suburbs to struggling downtown Detroit, and CEO Dan Gilbert opened a real estate arm (Bedrock) to acquire properties in the central business and financial district to house regional offices of Amazon, Twitter, Google and others.

2. Innovation District: A cluster of startups, incubators and companies, sometimes in partnership with local government.

  • York, Pennsylvania: The city is re-developing a 2-acre site to house robotics research, labs, alternative manufacturing, offices and temporary housing.

3. Vertically Integrated: Complex or high-rise with space for accelerators, labs, co-working and corporate offices, designed to let startups move through "stages" in one place.

  • Columbus: An old shoe factory was turned into a 65,000 square-foot facility for working areas, classrooms and workshops. The tenants were curated to house venture capital firms, lawyers, marketing agencies and other professional services to support the businesses setting up shop there.

4. Work-Live-Play: Mixed-use development that includes residential, commercial and entertainment and is pedestrian-friendly.

  • Orlando: Health-focused Lake Nona is a master-planned community that houses operations for Johnson & Johnson, Veterans Health Administration, and Nemours Children's Hospital.

Go deeper

Fintech's record year

Illustration: Annelise Capossela/Axios

Massive venture rounds into fintech companies have ballooned this year, pushing up total dollars invested — in just the first three quarters of 2021 — to nearly double the amount in all of 2020, per new PitchBook data.

Why it matters: The maturing of fintech startups means a growing number of companies are able to raise huge later-stage funding rounds as investors look to lock-in their bets.

Ben Geman, author of Generate
1 hour ago - Energy & Environment

Democrats' clean power outlook is very muddy

Illustration: Annelise Capossela/Axios

Here are two big questions as a key Democratic proposal to slash emissions from power generation flounders: how much its demise would sap climate protections, and what might replace it.

Catch up fast: New financial carrots and sticks for utilities to deploy zero-carbon power — the Clean Electricity Performance Program (CEPP) — look unlikely to stay in Democrats' big social spending and climate bill.

1 hour ago - Health

CDC: Unvaccinated are over 11 times more likely to die from COVID

Expand chart
Reproduced from CDC; Note: Data represents 30% of Americans across 16 jurisdictions: Alabama, Arizona, Arkansas, Colorado, Connecticut, Florida, Georgia, Idaho, Louisiana, Massachusetts, Michigan, Nebraska, New Mexico, New York City, Seattle/King County, Wash., Utah and Wisconsin; Chart: Danielle Alberti/Axios

The CDC recently published data evaluating Americans' rate of coronavirus cases and deaths by vaccine status, providing more data on which vaccines are working best and how much protection they offer relative to being unvaccinated.

What they found: As of August, unvaccinated people had a more than six times higher risk of testing positive for the coronavirus, and were more than 11 times more likely to die from the virus.