Sign up for our daily briefing

Make your busy days simpler with Axios AM/PM. Catch up on what's new and why it matters in just 5 minutes.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on the day's biggest business stories

Subscribe to Axios Closer for insights into the day’s business news and trends and why they matter

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Stay on top of the latest market trends

Subscribe to Axios Markets for the latest market trends and economic insights. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sports news worthy of your time

Binge on the stats and stories that drive the sports world with Axios Sports. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Tech news worthy of your time

Get our smart take on technology from the Valley and D.C. with Axios Login. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Get the inside stories

Get an insider's guide to the new White House with Axios Sneak Peek. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Axios on your phone

Get breaking news and scoops on the go with the Axios app.

Download for free.

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Denver news?

Get a daily digest of the most important stories affecting your hometown with Axios Denver

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Des Moines news?

Get a daily digest of the most important stories affecting your hometown with Axios Des Moines

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Twin Cities news?

Get a daily digest of the most important stories affecting your hometown with Axios Twin Cities

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Tampa Bay news?

Get a daily digest of the most important stories affecting your hometown with Axios Tampa Bay

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Charlotte news?

Get a daily digest of the most important stories affecting your hometown with Axios Charlotte

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios NW Arkansas

Stay up-to-date on the most important and interesting stories affecting NW Arkansas, authored by local reporters

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Illustration: Sarah Grillo/Axios

President-elect Joe Biden’s vow to restore America’s leadership in the world will be swiftly tested by resurgent adversaries, rudderless institutions and the gravest global health crisis in decades.

The big picture: Biden will face a familiar antagonist in Moscow, a stronger and more assertive China, a nuclear-armed North Korea, and an ongoing war in Afghanistan. That's not to mention a pandemic that’s ravaged the world and darkened the global economic outlook.

Biden’s approach to all of those challenges starts with revitalizing America’s alliances and restoring its credibility. His message is that “America is back” and “America first” is over.

  • Biden plans to quickly re-enter the Paris climate accord, recommit to NATO and re-engage with the World Health Organization.
  • He plans to put human rights back at the heart of U.S. foreign policy, and he has proposed a summit of the world’s democracies.
  • But Biden will have to prioritize the crises at home even as he aims to restore America's standing abroad.

Biden’s top domestic focus — containing the virus and its economic fallout — may also be his greatest foreign policy challenge.

  • Distributing vaccines globally will be particularly important. Competition over doses will drive resentment and prolong the pandemic, even if Americans get access relatively soon.
  • Multiple members of Biden's coronavirus task force have been sounding that alarm, portending a different approach from Biden after Trump shunned the WHO’s vaccine initiative.

Salvaging the Iran nuclear deal is near the top of Biden’s priority list. That would require lifting sanctions if Iran — which now has 12 times the amount of low-enriched uranium permitted under the deal — returns to compliance.

  • Iranian leaders have suggested they’d be willing to return to the old deal, but they dismiss talk of the broader follow-on agreement Biden envisions.
  • The Trump administration, meanwhile, is attempting to block the path back to the deal by piling on new non-nuclear sanctions that Biden might find politically tricky to lift.

Biden will have to move quickly to extend the New START nuclear treaty with Russia, which is set to expire 15 days after he takes office.

  • But he’s also vowed to confront Vladimir Putin over election interference and “impose real costs on Russia for its violations of international norms.”
  • Bill Burns, president of the Carnegie Endowment and a former ambassador to Moscow, told Axios it will be important for Biden to set the terms of the relationship early: “We’re going to be operating within a pretty narrow band of possibilities in dealing with Vladimir Putin’s Russia — from the sharply competitive to the pretty nastily adversarial."

North Korea may force itself onto Biden's agenda soon after he enters the White House. The regime has a history of testing incoming U.S. administrations.

  • Kim Jong-un's nuclear program has advanced significantly in the last four years, even as he has temporarily suspended testing.
  • The leaders aren’t starting on great terms. Biden called Kim a “thug” during the campaign, while North Korea labeled Biden a “rabid dog.”

Biden will also inherit a war in Afghanistan that he and Barack Obama vowed to end more than a decade ago.

  • U.S. troops are withdrawing from the country even as peace talks between the Taliban and Afghan government stall.
  • Biden plans to continue to pull troops out, but he may leave a counterterrorism force behind.

Go deeper

John Kerry: U.S.-China climate cooperation is a "critical standalone issue"

President Biden's special climate envoy John Kerry said Wednesday that the U.S. must deal with China on climate change as a "critical standalone issue," but stressed that confronting Beijing's human rights and trade abuses "will never be traded" for climate cooperation.

Why it matters: The last few years have brought about a bipartisan consensus on the threat posed by China. But as the largest emitter of greenhouse gases, China will be a vital player if the world is going to come close to reining in emissions on the scale needed to meet the Paris Agreement goals of limiting warming to 2°C above pre-industrial levels.

35 mins ago - Health

Internal CDC presentation warns: "The war has changed"

Graphic: CDC via The Washington Post

Unpublished research indicates that the Delta variant causes more severe illness and spreads as easily as chickenpox, and that vaccinated people may transmit the strain as easily as those who are unvaccinated, according to an internal CDC presentation obtained by WashPost.

Why it matters: The data played a key role in the CDC's decision to tell vaccinated people to resume masking indoors, with the presentation calling on health officials to "acknowledge the war has changed," The Post reports.

Updated 39 mins ago - Sports

Olympics dashboard

Women's 5,000 meter heats at the Tokyo Olympics. Photo: Jewel Samad/AFP via Getty Images

🎾: Novak Djokovic defeated in Olympic semi-finals

🗓: The Olympic events to watch today

🏊‍♀️: South Africa's Tatjana Schoenmaker breaks world record in 200m breaststroke

🏊: Olympic swimmer Ryan Murphy wins Silver in 200m

🚣‍♀️: Team USA women's eight rowing fails to reach the podium

💻: Japan tests teleporting games and "remote cheering"

Go deeper: Full Axios coverage