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Protestors rallying against repealing and replacing the Affordable Care Act in 2017. Photo: Albin Lohr-Jones/Pacific Press/LightRocket/Getty Images

Republican attorneys general and the Trump administration will make their case before the 5th Circuit Court of Appeals Tuesday for striking down the entire Affordable Care Act.

Why it matters: If all of this ends with the Affordable Care Act being struck down, it'll kick millions of people off their coverage, upend the health care system and force the political debate about health care back into 2010-level intensity.

  • That hasn't happened yet and it may not happen, but the 5th Circuit is the last stop before the Supreme Court, so buckle up.

What we're watching:

  • Severability: It wouldn't be too hard to throw out what remains of the ACA's individual mandate but leave the rest of the law intact. That outcome didn't seem to interest Judge Reed O'Connor, the lower-court judge who said last year the whole law had to go, but it could get a second chance today.
  • Congressional intent: Congress said in 2010 that the individual mandate was intertwined with the law's other coverage provisions, most notably its protections for people with pre-existing conditions. But it was also Congress that redesigned the law, keeping those protections in place but nullifying the mandate. Does the 111th Congress' intent override the 115th's?

Go deeper: Trump privately thinks ACA lawsuit will fail in court

Go deeper

53 mins ago - Health

Study: Common antidepressant guards against COVID hospitalization

A COVID-19 intensive Care Unit in Rio De Janeiro, Brazil on May 27, 2021. Photo: Fabio Teixeira/Anadolu Agency via Getty Images

The readily available antidepressant fluvoxamine significantly reduced COVID-related hospitalizations, according to a large study published Wednesday.

Why it matters: The clinical trial suggests that a cheap, readily available drug could dramatically reduce serious illness and death when prescribed early.

By the numbers: Catholics, Biden and abortion

Expand chart
Reproduced from Pew Research Center; Chart: Axios Visuals

President Biden — the second Catholic U.S. president — will meet with Pope Francis at the Vatican on Friday, as some church leaders debate whether to deny Holy Communion to politicians who support abortion rights.

By the numbers: Overall, two in three U.S. Catholics believe Biden should be allowed to take Communion despite his stance on abortion, according to polling by Pew Research Center.

Texas House probes school library books dealing with race and sexuality

Photo: Brittany Murray/MediaNews Group/Long Beach Press-Telegram via Getty Images

Texas state Rep. Matt Krause, chair of the Texas House Committee on General Investigating, announced Wednesday that he's initiating a probe into schools' library books, according to a letter sent to the state's education agency and other superintendents.

Why it matters: The probe focuses on books that discuss race, sexuality or "make students feel discomfort, guilt, anguish or any other form of psychological distress because of their race or sex," Krause wrote in the letter.