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In this image of neurons, tau proteins are stained red (Gerry Shaw / Wikipedia)

Scientists have taken detailed images of one of the proteins involved in Alzheimers Disease for the first time, which may help researchers create treatments for the disease.

Alzheimers is characterized by a buildup of two proteins, tau proteins inside of neurons and amyloid plaques on the outside. Healthy tau proteins look sort of like fiber-optic cables that help support neurons. But sometimes, those proteins become tangled, and the tangles can build up and warp the neuron's shape, rendering them useless.

Why it matters: Tau tangles have been implicated in a number of neuro-degenerative diseases, including Alzheimer's, Huntington's and Parkinson's Disease. These detailed images allow scientists to parse apart the molecular structure of the tangles, which could help them understand why the tangles happen, how they spread, and possibly even develop drugs to treat them.

What they did: The scientists, working at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, and the Indiana University School of Medicine in Indianapolis used a technique called cryo-electron microcopy or cryo-EM to image tau tangles from the brain of a 86-year-old woman who died while ill with Alzheimer's. Their paper was published Wednesday in the journal Nature.

Electron micrograph of tau filaments. Two different types of filaments are flagged with blue and green arrows.Fitzpatrick et al 2017

Slow down: It still isn't clear if tau tangles, amyloid plaques or something else cause Alzheimer's. Some research suggests that the two work together, while other studies suggest that amyloids could be red herrings. Even if treating tau proteins helps treat Alzheimers, it could be decades before any tau-targeting treatments hit the market. Still, this molecular understanding is a big step.

What's next: The researchers hope that by imaging tau proteins in other diseases, they'll be able to see if they form similarly or differently than Alzheimer's tau tangles.

Go deeper

Updated 4 hours ago - World

U.S. airstrike kills senior al-Qaeda leader in Syria, DOD says

A displacement camp near the village of Qah in Syria's northwestern Idlib province. Photo: Ahmad Al-Atrash/AFP via Getty Images

A U.S. airstrike in northwest Syria on Friday killed senior al-Qaeda leader Abdul Hamid al-Matar, U.S. Central Command said in a statement.

Why it matters: Syria serves as a "safe haven" for the extremist group to plan external operations, according to U.S. Army Maj. John Rigsbee.

Updated 9 hours ago - Politics & Policy

Giuliani associate Lev Parnas convicted of campaign finance crimes

Lev Parnas, a former associate of then-President Donald Trump’s personal lawyer Rudy Giuliani. Photo: Stefani Reynolds/Bloomberg via Getty Images

Florida businessman Lev Parnas was convicted Friday on charges of conspiracy to make foreign contributions to political campaigns, according to multiple outlets.

Why it matters: Prosecutors said Parnas, then an associate of former President Donald Trump's personal lawyer Rudy Giuliani, funneled over $150,000 from a Russian businessman into U.S. campaigns as part of an effort to land licenses in the U.S.'s legal cannabis industry.

Supreme Court agrees to hear challenges to Texas abortion law

Photo: Saul Loeb/AFP via Getty Images

The Supreme Court on Friday agreed to hear two cases challenging Texas' abortion law, which bans the procedure as soon as six weeks into pregnancy, but left the law in place in the meantime.

Why it matters: The court is moving extraordinarily fast on the Texas cases, compressing into just a few days a process that normally takes months. And that schedule means the court will take up Texas' ban a month before it hears another major abortion case — a challenge to Mississippi's own 2018 ban on abortions after 15 weeks.

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