May 10, 2017

A new way to fight drug-resistant bacteria

Janice Haney Carr / CDC

Chemists have figured out a way to get through the thick outer membrane found in some bacteria, which they say could lead to new antibiotics for drug-resistant infections.

Why it matters: Drug-resistant bacteria pose a serious global health threat. In the U.S. alone, an estimated 23,000 people die each year from infections that can't be fought with existing antibiotics. E.Coli, acetinobacter that can be picked up in hospitals, and other types of bacteria with a tough outer membrane are becoming increasingly resistant to drugs. Efforts to create new antibiotics have come up short because they can't get into the cell.

How it works: Chemists at the University of Illinois Urbana-Champaign tested 180 different compounds that could penetrate E. Coli and figured out what features allowed some to make it through the cell membrane. Using those attributes, they then modified a natural compound that works on the other class of bacteria (without an outer membrane) and found it could then penetrate both types of microbes.

What's next: Getting in is step one — a compound would also have to kill the bug. The researchers point out that the compound itself may not work for treatment but that they now have a list of features that they hope can guide discovery and development of new drugs.

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The cost of going after Bloomberg

Illustration: Eniola Odetunde/Axios

Here's the growing dilemma for 2020 Democrats vying for a one-on-one showdown with frontrunner Bernie Sanders: Do they have the guts — and the money — to first stop Mike Bloomberg?

Why it matters: Joe Biden, Pete Buttigieg, Amy Klobuchar and Elizabeth Warren all must weigh the costs of punching Bloomberg where he looks most vulnerable: stop-and-frisk, charges of sexism, billionaire entitlement. The more zealous the attacks, the greater the risk he turns his campaign ATM against them.

How Trump’s economy stacks up

Source: "Presidents and US Economy", Trump figures through 2019 courtesy of Alan Blinder; Note: Data shows real GDP and Q1 growth in each term is attributed to the previous president; Chart: Axios Visuals

Average economic growth under President Trump has outpaced the growth under Barack Obama, but not all of his recent predecessors.

Why it matters: GDP is the most comprehensive economic scorecard — and something presidents, especially Trump, use as an example of success. And it's especially relevant since Trump is running for re-election on his economic record.

Coronavirus cases rise as 14 American evacuees infected

Data: The Center for Systems Science and Engineering at Johns Hopkins, the CDC, and China's NHC; Note: China refers to mainland China and the Diamond Princess is the cruise ship offshore Yokohama, Japan. Map: Danielle Alberti/Axios

14 Americans evacuated from the Diamond Princess cruise ship tested positive for the novel coronavirus before being flown in a "specialist containment" on a plane repatriating U.S. citizens back home, the U.S. government said early Monday.

The big picture: COVID-19 has now killed at least 1,770 people and infected almost 70,000 others. Most cases and all but five of the deaths have occurred in mainland China. Taiwan confirmed its first death on Sunday, per multiple reports, in a 61-year-old man with underlying health conditions. Health officials were investigating how he became ill.

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