Sen. Bill Cassidy loses Louisiana Republican Senate primary

Driving the news: Cassidy ran afoul of Trump when he voted more to convict the president during his Senate impeachment trial over the Jan. 6, 2021, riot at the U.S. Capitol.

• Trump was acquitted, but he's sought retribution against Republicans who supported the impeachment effort.

Between the lines: Cassidy also helped torpedo Casey Means' nomination for surgeon general, a move that drew the ire of Health Secretary Robert F. Kennedy Jr. and the MAHA movement.

• Means, a health influencer, is a close Kennedy ally and a major figure in the MAHA movement. She is also the sister of Calley Means, a top Kennedy adviser.
• Kennedy and his supporters view Cassidy, a physician-turned-senator who chairs the Senate HELP Committee, as an avatar for the medical establishment they're determined to upend, as Axios' Alex Isenstadt wrote.

Zoom in: Saturday marked the first time in more than 50 years that Louisiana used a closed-primary system to choose its U.S. senator, a change widely viewed as putting Cassidy at a disadvantage.

• In his previous primary victories, Cassidy's main opposition came from Democrats.
• Trump endorsed Letlow, a U.S. House member from the northeastern part of the state, in January.
• Fleming cast himself as a Trump and MAGA ally, despite not having the president's endorsement.

The big picture: Trump is now two-for-two on his political revenge tour.

• Earlier this month, Trump helped steamroll a bloc of Indiana Republican legislators who resisted his effort to redraw the state's congressional map.
• Next up: Kentucky, where Trump is looking to unseat arch-nemesis Rep. Thomas Massie on Tuesday.