Vance is a major break from decades of Republican VP nominees who called themselves Reagan Republicans, including former Vice President Mike Pence.
The big picture: Vance is all-in on the most distinct areas in which Trumpism has diverged from Reaganism.
Economy: "Vance believes that decades of liberalized global trade and immigration to the United States have been damaging for U.S. workers," Axios Macro co-author Neil Irwin writes.
"Vance may emerge as a voice within the administration with whom business interests and traditional Reaganites clash."
Foreign policy: Vance was one of the first Senate Republicans to openly say they weren't concerned with Ukraine aid. "I don't really care what happens to Ukraine one way or the other," he said in 2022.
"What worries the hawks is that Vance may also be the last adviser in the former president's ear," Jonathan Martin reports for Politico.
Elections and voting: Vance would have acted differently than Pence on Jan. 6, 2021, he said earlier this year on ABC News.
"If I had been vice president, I would have told the states, like Pennsylvania, Georgia and so many others that we needed to have multiple slates of electors and I think the U.S. Congress should have fought over it from there."
