House Energy and Commerce Chair Cathy McMorris Rodgers' retirement casts uncertainty over the fate of House's transparency package, post-COVID oversight of federal health agencies and legislation addressing disability rights.

The big picture: The health cost transparency package may be seen as her signature health achievement, which includes narrow site-neutral measures, PBM transparency provisions and new requirements on hospitals and insurers.

What's next: E&C health subcommittee chair Brett Guthrie's spokesman confirmed to Axios that he will run for the full committee chairmanship.

• Another name that lobbyists floated was Rep. Bob Latta, who's another senior member of the committee.

Between the lines: Rodgers joins two other prominent E&C members who were active on health policy and are departing at the end of this Congress: Reps. Michael Burgess and Larry Bucshon.

• McMorris Rodgers notched some bipartisan wins, as with the transparency package. But she also held the GOP line by, for example, resisting calls to address drug shortages in a pandemic preparedness reauthorization.
• This month she also subpoenaed NIH for documents and information related its handling of sexual harassment complaints within the agency and its grantee institutions.

What we're watching: Whether CMR's early retirement announcement will weaken her hand in negotiations with the Senate over a transparency package, or on other health priorities, such as PAHPA, telehealth programs and Medicare payment reform.