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Experts divided on trend toward smaller, targeted clinical trials

 Senior scientist Zhou Han sets up a quantitative PCR (polymerase chain reaction) to check the effect of a drug in cell assays at Stoke Therapeutics.
Senior scientist Zhou Han at Stoke Therapeutics, which is looking for a cure for epilepsy. Photo: Pat Greenhouse/The Boston Globe via Getty Images

Researchers are turning to smaller, more narrowly targeted clinical trials to test the next generation of medicines, The Wall Street Journal reports. Experts are divided over the shift: smaller trials make sense for more personalized treatments, but incremental benefits often are only discovered with a lot of data.

By the numbers: The number of clinical trials funded by the National Institutes of Health fell by 41% from 2005 to 2015, according to the WSJ, largely because trials have gotten more expensive.