An image grab taken from a video obtained by AFPTV shows US troops gathered at the scene of a suicide attack in the northern Syrian town of Manbij. Photo: AFP/Getty Images

Four Americans were killed and three wounded during an explosion in Manbij, Syria, U.S. officials said on Wednesday.

Details: The Islamic State, or ISIS, has claimed responsibility for the attack. According to CENTCOM, the Americans killed included two service members, one Defense Department civilian and one contractor.

The big picture: The Trump administration began the process for withdrawing its 2,000 troops in Syria last week. President Trump has spent the past few months downplaying the threat of ISIS in Syria and the need for an ongoing U.S. military presence in the country.

  • About an hour after officials confirmed U.S. troops were killed, Vice President Mike Pence gave a speech declaring that "ISIS has been defeated," CNN reports. He reportedly did not mention the attack or offer his condolences.

Go deeper: The U.S. is leaving Syria, and will stay as long as it takes

Go deeper

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Photo: Anwar Amro/AFP via Getty Images

A major explosion has slammed central Beirut, Lebanon, and damaged buildings as far as several miles away.

Driving the news: The cause of the explosion is unknown, as are details of potential deaths and injuries. It comes as Lebanon grapples with a crippling financial crisis and the ongoing effects of the coronavirus pandemic.

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  4. Public health: 40% of Americans continue to put off medical care.
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  6. Business: Low-income households are struggling to pay energy bills — Construction spending falls for 4th straight month.

Trump's new TikTok threat

Photo illustration: Aïda Amer/Axios. Photo: Jim Watson/AFP via Getty Images

President Trump said twice Monday that the U.S. Treasury would need to get a portion of the sale price of TikTok, as a condition of regulatory approval.

Why it matters: This is akin to extortion — the sort of thing you'd expect to hear on a wiretap, not from the White House in front of reporters.