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An image grab taken from a video obtained by AFPTV shows US troops gathered at the scene of a suicide attack in the northern Syrian town of Manbij. Photo: AFP/Getty Images

Four Americans were killed and three wounded during an explosion in Manbij, Syria, U.S. officials said on Wednesday.

Details: The Islamic State, or ISIS, has claimed responsibility for the attack. According to CENTCOM, the Americans killed included two service members, one Defense Department civilian and one contractor.

The big picture: The Trump administration began the process for withdrawing its 2,000 troops in Syria last week. President Trump has spent the past few months downplaying the threat of ISIS in Syria and the need for an ongoing U.S. military presence in the country.

  • About an hour after officials confirmed U.S. troops were killed, Vice President Mike Pence gave a speech declaring that "ISIS has been defeated," CNN reports. He reportedly did not mention the attack or offer his condolences.

Go deeper: The U.S. is leaving Syria, and will stay as long as it takes

Go deeper

Updated 2 hours ago - World

Fatal stabbing of British MP David Amess declared a terrorist incident

Police outside Belfairs Methodist Church in Leigh-on-Sea, England, on Oct. 15. Photo: John Keeble/Getty Images

Authorities have declared the death of David Amess a terrorist incident, hours after the Conservative Party lawmaker in the U.K. was fatally stabbed while meeting with local constituents in a church in eastern England on Friday.

The big picture: The Metropolitan Police has found "a potential motivation linked to Islamist extremism."

Biden: DOJ should prosecute those who defy Jan. 6 subpoenas

President Biden speaks with reporters at Bradley International Airport in Windsor Locks, Connecticut. Photo: Brendan Smialowski/AFP via Getty Images

President Biden said Friday that the Justice Department should prosecute those who defy subpoenas from the Jan. 6 select committee.

Why it matters: The president's remarks come one day after Donald Trump ally Steve Bannon failed to show up for a deposition before the committee.

Updated 3 hours ago - Politics & Policy

Bill Clinton hospitalized for non-COVID-related infection

Former President Bill Clinton. Photo: Win McNamee/Pool/AFP via Getty Images

Former President Bill Clinton was admitted to the University of California, Irvine Medical Center on Tuesday for a non-COVID-related infection, his spokesperson Angel Ureña said Thursday.

The latest: In an update on Friday, Ureña said Clinton's health indicators are "trending in the right direction, including his white blood count which has decreased significantly."