Dec 13, 2017

Inside Alphabet's big anti-aging bet

Calico chief computing officer Daphne Koller. Photo: Neilson Barnard/Getty

Anti-aging company Calico has remained fairly quiet since being formed in 2013 via around a $1 billion investment from Google. But that changed a bit today when senior executive Daphne Koller was interviewed at a San Francisco conference hosted by CB Insights:

Aging is a universal societal problem.
— Daphne Koller, Calico's chief computing officer and former CEO of Coursera

Koller says that Calico's primary research involves 750 mice, which are broken into five groups based on different regimes of caloric intake. The idea is to get a better sense of the aging trajectory of mammalian organisms and how caloric intake — the "one intervention shown to extend life among multiple species" — can also be affected by genetics and the environment.

  • One major difficulty of anti-aging work is that Calico needs to have complete data on an organism from life to death. If the company eventually begins clinical research on humans, it means those who begin a study are unlikely to be around to finish it.

Calico also is exploring the issue of cellular aging since, as Koller says, "as cells age, a lot of stuff begins to go wrong." It's using yeast cells for this research, and its engineers have developed a "yeast tracker" so they can determine the age of a yeast cell without having to constantly stare into a microscope or review countless hours of video to identify cell divisions.

"I don’t think we’re secretive so much as we don’t like to talk about our work until it’s complete," Koller said.

Go deeper

In photos: Deadly Storm Dennis lashes U.K., Ireland and western France

A family is rescued from a property in Nantgarw, Wales, on Sunday. The storm comes a week after the U.K. was battered by storm Ciara, which killed two people, per the BBC. Photo: Matthew Horwood/Getty Images

Storm Dennis continued to pummel parts of England, Wales and Ireland over Sunday night with heavy rain after battering Northern Ireland and Scotland, per the official British weather agency the Met Office.

Why it matters: It's the second-strongest nontropical storm ever recorded in the North Atlantic Ocean, with its hurricane-force winds and heavy rains that caused widespread flooding across the U.K., the Washington Post notes. Police in Wales confirmed Sunday they found the body of a man who fell into a river as the storm lashed Ystradgynlais.

See photosArrow53 mins ago - World

Sanders accuses Bloomberg of trying to "buy" the 2020 election

Sen. Bernie Sanders and Mike Bloomberg. Photos: Drew Angerer; Brett Carlsen/Getty Images

Sen. Bernie Sanders tore into 2020 rival Michael Bloomberg at a Las Vegas campaign event Saturday, saying the billionaire and former New York mayor is trying to "buy the presidency" by paying millions of dollars in advertising.

Why it matters: Bloomberg has surged in national polling recently, having poured millions of dollars into campaign ads largely targeting Trump. His candidacy has become an obvious foil for Sanders, whose grassroots campaign railing against billionaires and the establishment has vaulted him to front-runner status.

Go deeperArrowUpdated 2 hours ago - Politics & Policy

Coronavirus cases rise, as more Americans on cruise confirmed ill

Data: The Center for Systems Science and Engineering at Johns Hopkins, the CDC, and China's NHC; Note: China refers to mainland China and the Diamond Princess is the cruise ship offshore Yokohama, Japan. Map: Danielle Alberti/Axios

A U.S. public health official confirms more than 40 Americans on the Diamond Princess cruise ship off Japan have coronavirus, while the remaining U.S. citizens without symptoms are being evacuated.

The big picture: COVID-19 has now killed at least 1,770 people and infected almost 70,000 others. Most cases and all but five of the deaths have occurred in mainland China. Taiwan confirmed its first death on Sunday, per multiple reports, in a 61-year-old man with underlying health conditions. Health officials were investigating how he became ill.

Go deeperArrowUpdated 5 hours ago - Health