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Calico chief computing officer Daphne Koller. Photo: Neilson Barnard/Getty

Anti-aging company Calico has remained fairly quiet since being formed in 2013 via around a $1 billion investment from Google. But that changed a bit today when senior executive Daphne Koller was interviewed at a San Francisco conference hosted by CB Insights:

Aging is a universal societal problem.
— Daphne Koller, Calico's chief computing officer and former CEO of Coursera

Koller says that Calico's primary research involves 750 mice, which are broken into five groups based on different regimes of caloric intake. The idea is to get a better sense of the aging trajectory of mammalian organisms and how caloric intake — the "one intervention shown to extend life among multiple species" — can also be affected by genetics and the environment.

  • One major difficulty of anti-aging work is that Calico needs to have complete data on an organism from life to death. If the company eventually begins clinical research on humans, it means those who begin a study are unlikely to be around to finish it.

Calico also is exploring the issue of cellular aging since, as Koller says, "as cells age, a lot of stuff begins to go wrong." It's using yeast cells for this research, and its engineers have developed a "yeast tracker" so they can determine the age of a yeast cell without having to constantly stare into a microscope or review countless hours of video to identify cell divisions.

"I don’t think we’re secretive so much as we don’t like to talk about our work until it’s complete," Koller said.

Go deeper

Trump impeachment trial to start week of Feb. 8, Schumer says

Senate Majority Leader Chuck Schumer. Photo: The Washington Post via Getty

The Senate will begin former President Trump's impeachment trial the week of Feb. 8, Majority Leader Chuck Schumer announced Friday on the Senate floor.

The state of play: Schumer announced the schedule after reaching an agreement with Republicans. The House will transmit the article of impeachment against the former president late Monday.

1 hour ago - Health

CDC extends interval between COVID vaccine doses for exceptional cases

Photo: Joseph Prezioso/AFP via Getty

Patients can space out the two doses of the coronavirus vaccine by up to six weeks if it’s "not feasible" to follow the shorter recommended window, according to updated guidance from the Centers for Disease and Control and Prevention.

Driving the news: With the prospect of vaccine shortages and a low likelihood that supply will expand before April, the latest changes could provide a path to vaccinate more Americans — a top priority for President Biden.

Texas AG sues Biden administration over deportation freeze

Texas Attorney General Ken Paxton speaks to members of the media in 2016. Photo: Alex Wong/Getty Images

Texas Attorney General Ken Paxton is suing the Biden administration in federal district court over its 100-day freeze on deporting unauthorized immigrants, and he's asking for a temporary restraining order.

Between the lines: The freeze went into effect Friday, temporarily halting most immigration enforcement in the U.S. In the lawsuit, Paxton claims the move "violates the U.S. Constitution, federal immigration and administrative law, and a contractual agreement between Texas" and the Department of Homeland Security.