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Andrew Harnik / AP

The staff fired this week were in one of the few top offices that directly report to the Secretary of State Rex Tillerson (the office of the Deputy Secretary of State for Management and Resources, per CBS.

Why this matters: A former State Department official told Axios the Deputy Secretary of State may have to pick up the slack for this empty office, which may rob the State Department of focused regional policy-making and guidance that helps U.S. diplomats do their job.

"Given the current environment I don't know why you wouldn't take advantage" of the management office, a former senior State Department official told Axios, referring to the other four senior management State officers who were recently asked to pack their bags.

The buzz around State is that Trump could be planning to eliminate this office, a current senior State Department official told Axios.

This adds to the signals that the White House is trying to step up its role in foreign policy. The senior State Department official told Axios this is normal, but that the POTUS traditionally works through the National Security Council. These dismissals also add to the concern that diplomats' ability to influence policy is already under attack since Sean Spicer said diplomats can "either get with the program or they can go" after hundreds signed a dissent channel a few weeks ago.

Go deeper

1 hour ago - Health

Pfizer says COVID vaccine over 90% effective in kids

A health care worker preparing a Pfizer-BioNTech coronavirus vaccine dose in New York City on Oct. 21. Photo: Michael M. Santiago/Getty Images

Pfizer and BioNTech said their COVID-19 vaccine was more than 90% effective at protecting children between the ages of 5 and 11 from symptomatic infections from the virus, according to a study posted online by the Food and Drug Administration Friday.

Why it matters: Pfizer is seeking an emergency use authorization to vaccinate children — one of the last groups of Americans still largely ineligible to receive a coronavirus vaccine.

Changing the inflation conversation

Illustration: Annelise Capossela/Axios

Inflation looks like it’ll run hot for longer than plenty of smart people thought it would. The conversation over just how much more Americans will have to pay for their stuff has taken on a new intensity, as supply problems show few signs of fading.

Why it matters: The rate of price growth has remained consistently strong in recent months — a time that some thought would bring cooling prices after an initial reopening spike. What goes on with prices will influence the decisions made by Congress, the Biden Administration, and the Federal Reserve.

The biggest headline from Biden's town hall

President Biden greets attendees during a commercial break in Baltimore last night. Photo: Nicholas Kamm/AFP via Getty Images

What matters from President Biden's town hall with CNN's Anderson Cooper at Baltimore Center Stage on Thursday:

The biggest headline: Biden is jettisoning the corporate tax increases that White House officials have insisted, for the past 10 months, are wildly popular across the country. He admitted he doesn't have the votes.