Robert F. Bukaty/AP

Scientists have discovered that a receptor in the body that THC binds to is malleable, re-igniting the possibility of drugs that mimic cannabis, Wired reported.

Why this matters: Researchers have long sought to develop chemicals that offer the benefits of marijuana, such as pain relief and anti-nausea, without the unwanted side effects of getting high.

How it works: When someone smokes, THC binds to CB1 receptors on the surface of cells in the brain, liver, lungs and elsewhere in the body. This interaction causes the cells to release chemical signals that lead to the typical side effects of smoking like hunger, anxiety, and euphoria, for example. Previous years of research suggested that CB1 receptors only responded to a specific chemical, like a lock and key.

The new discovery: Alexandros Makriyannis, director of Northeastern University's Center for Drug Discovery, along with a team of researchers from China, California, and Florida used X-ray crystallography to see the interaction between the receptor and compounds similar to THC. They found when THC-like molecules went into the receptor, it twisted to fit around the molecule and shrunk down to about half of its original size. Rather than react in a single, specified manner to cannabinoids, the receptors are flexible. "We want to make compounds that will modify the receptor differently, so we can make better drugs," Makriyannis told Wired.

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Americans reflect on Independence Day amid racism reckoning

A Black Lives Matter banner and a United States flag on the facade of the U.S. embassy building in Seoul, South Korea. Photo: Simon Shin/SOPA Images/LightRocket via Getty Images

America's leaders are rethinking how they view Independence Day, as the country reckons with the historic, unequal treatment of people of color during a pandemic which has disproportionately affected nonwhite Americans.

Why it matters: The country’s legacy of racism has come into sharp focus in the weeks of protests following the death of George Floyd while in Minneapolis police custody. From Confederate statues to Mount Rushmore, Americans are reexamining the symbols and traditions they elevate and the history behind them.

Updated 3 hours ago - Politics & Policy

Coronavirus dashboard

Illustration: Aïda Amer/Axios

  1. Global: Total confirmed cases as of 2 p.m. ET: 10,945,600 — Total deaths: 523,035 — Total recoveries — 5,797,206Map.
  2. U.S.: Total confirmed cases as of 2 p.m. ET: 2,767,669 — Total deaths: 128,951 — Total recoveries: 781,970 — Total tested: 33,462,181Map.
  3. Public health: The states where face coverings are mandatory Fauci says it has been a "very disturbing week" for the spread of the coronavirus in the U.S.
  4. Economy: The economy may recover just quickly enough to kill political interest in more stimulus.
  5. States: Florida reports more than 10,000 new coronavirus cases, and its most-infected county issues curfew.
5 hours ago - Sports

Washington Redskins to review team name amid public pressure

Photo: Patrick McDermott/Getty Images

The Washington Redskins have announced they will be conducting a review of the team's name after mounting pressure from the public and corporate sponsors.

Why it matters: This review is the first formal step the Redskins are taking since the debate surrounding the name first began. It comes after weeks of discussions between the team and the NFL, the team said.