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Alton Strupp / The Courier-Journal via AP

The FDA just put out a report that's making the rounds among health care wonks. It's about 22 clinical trials of new drugs where the results in the early trials were wildly different than they were in the later, broader ones.

Here's what Joshua Sharfstein, a former FDA deputy commissioner and former secretary of the Maryland health department, tweeted about the report:

Why it matters: It's likely to provide new ammunition to the FDA's defenders as Republicans in Congress, and some Democrats, push for speedier approvals of new drugs. The report listed cases where the Phase 3 trials — which are conducted on broader groups of people than the earlier Phase 2 trials — showed that the new drugs might not be effective or safe, or both.

Go deeper

Dan Primack, author of Pro Rata
2 hours ago - Politics & Policy

Democrats' billionaires tax explained

Illustration: Aïda Amer/Axios

There is now legislative language behind the push to tax American billionaires on unrealized capital gains, as Sen. Ron Wyden last night released his 107-page plan.

Why it matters: This would be a sea change in U.S. tax policy, which has only applied to realized gains (otherwise known as income).

3 hours ago - World

Scoop: Blinken protests Israel settlements approval in "tense" phone call

Benny Gantz (L) and Tony Blinken. Photo: Jacquelyn Martin/Pool/AFP via Getty

Secretary of State Tony Blinken protested the decision to approve 3,000 new housing units in Israeli settlements in the occupied West Bank during a tense phone call on Tuesday with Israeli Defense Minister Benny Gantz, three Israeli officials tell me.

Why it matters: This is the first time new construction in the settlements has been approved since President Biden assumed office, and the Biden administration had been privately pressing the Israeli government not to proceed.

The startup that wants to disrupt big internet providers

Illustration: Maura Losch/Axios

A new startup backed by funding from AOL founder Steve Case and Laurene Powell Jobs wants to break up broadband monopolies across the country.

Why it matters: Internet access has been crucial during the pandemic, but it's not ubiquitous, and it can be both slow and unaffordable in swaths of the country.