In the two months since signing the $1 trillion infrastructure bill into law, President Biden has by almost every measure bombed big time on the things that matter most.

The big picture: Biden, who marks one year in office next Thursday, has never been less popular nationally, after personally lobbying his party and the public on Build Back Better and voting rights — and failing.

President Biden met with Sens. Joe Manchin (D-W.Va.) and Kyrsten Sinema (D-Ariz.) at the White House on Thursday night to discuss voting rights after they reaffirmed their opposition to reforming the filibuster, per the White House.

Why it matters: Biden and other Democrats want the Senate's filibuster rules changed in order to pass voting rights legislation.

President Biden will nominate Sarah Bloom Raskin as the Federal Reserve's top Wall Street cop, a Biden administration official said, one of three nominees being unveiled for the critical open seats on the central bank's board of governors.

Why it matters: It's Biden's biggest mark yet on the influential economic body that's center stage as the country grapples with inflation rising at the fastest pace in decades and a recovering labor market.

The Biden administration is expanding efforts to speed clean electricity expansion with its existing powers, but faces big obstacles to meeting its climate goals without far more help from Congress.

Why it matters: President Biden has set a goal of reaching 100% carbon-free power by 2035 and cutting economy-wide greenhouse gas emissions — that is, power, transport, industry, etc. — in half by 2030.

President Biden on Thursday announced a "surge" deployment of military medical personnel to support hospitals currently dealing with a spike of COVID-19 cases largely driven by the Omicron variant.

Driving the news: Omicron's surge in cases has led to a "high number of total hospitalizations," and hospitals are having to treat "more and more patients in the midst of staffing challenges and faced with a highly transmissible virus that does not spare our health care workers," CDC director Rochelle Walensky said on Wednesday.

NBC News White House correspondent Mike Memoli — who may hold the record for serving in Joe Biden pools — plans a book about President Biden, "The Long Run," coming from Twelve Books after the 2024 election.

Why it matters: Memoli has covered Biden, his family, and his inner circle of advisers for more than a dozen years.

Robert Califf, President Biden's nominee to lead the FDA, is facing a surprisingly tight confirmation vote in the Senate.

Between the lines: A handful of Democrats have already announced their opposition to him over concerns about his drug industry ties or the FDA's record on the opioid epidemic, and several others may be on the fence.

• But abortion politics — not to mention the opportunity to sink a Biden nominee — are complicating efforts to make up for these defectors with Republican votes.

Former President Obama threw his support behind changing the filibuster on Wednesday in an op-ed that emphasized the need to "vigilantly preserve and protect" the right to vote.

Why it matters: The move comes a day after President Biden publicly backed rule changes to the filibuster this week to ensure the Senate passes Democrats' voting rights legislation.

Senate Minority Leader Mitch McConnell (R-Ky.) on the Senate floor Wednesday slammed President Biden's voting rights speech, calling it "divisive" and "profoundly unpresidential."

Why it matters: In his Tuesday remarks in Atlanta, Biden backed changing the filibuster to ensure voting rights are protected, and blasted Senate Republicans for blocking action on the issue.

President Biden on Tuesday called the Jan. 6 Capitol insurrection an attempted "coup."

Why it matters: In a speech on voting rights in Atlanta, Biden used strong language to lambast former President Trump and his supporters for trying to "win through violence what he had lost at the ballot box."