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A team of scientists may have developed a new opioid alternative that kills pain while muting the addictive components, according to a new study of animal models in Science Translational Medicine published yesterday.

Why it matters: From 1999 to 2016, more than 200,000 Americans died from overdoses related to prescription opioids, my colleague Eileen Drage O'Reilly reports. Yet, these drugs remain the most effective options for treating many cases of acute or chronic pain.

  • Several of the authors who are claiming success are employees of Astraea Therapeutics, which is developing the potential drug.
  • Read the whole thing to understand how the science of the new compound works.

Meanwhile, the Food and Drug Administration announced yesterday that it's replacing 2014 guidance on developing new pain drugs with a more efficient, focused approach.

  • Commissioner Scott Gottlieb told the Washington Postthat the 2014 guidance is overly broad and that the new agency guidance should lead to smaller clinical trials, faster approvals and quicker launches of new therapies.

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Updated 24 mins ago - Politics & Policy

Coronavirus dashboard

Illustration: Annelise Capossela/Axios

  1. Politics: Trump says if Biden's elected, "he'll listen to the scientists"Trump calls Fauci a "disaster" on campaign call.
  2. Health: Coronavirus hospitalizations are on the rise — 8 states set single-day coronavirus case records last week.
  3. States: Wisconsin judge reimposes capacity limit on indoor venues.
  4. Media: Trump attacks CNN as "dumb b*stards" for continuing to cover pandemic.
  5. Business: Consumer confidence surveys show Americans are getting nervousHow China's economy bounced back from coronavirus.
  6. Sports: We've entered the era of limited fan attendance.
  7. Education: Why education technology can’t save remote learning.
2 hours ago - Health

Trump attacks CNN as "dumb b*stards" for continuing to cover pandemic

President Trump attacked CNN for continuing to cover the coronavirus pandemic, calling the network "dumb b*stards" at a campaign rally in Prescott, Arizona on Monday.

Why it matters: The president's attacks on the media and Anthony Fauci, the government's top infectious-disease expert, come as coronavirus cases and hospitalizations are again surging across the country, just two weeks out from Election Day.

3 hours ago - World

Deal to remove Sudan as terror sponsor paves way for Israel move

President Trump announced Monday that he will be removing Sudan from the State Department’s state sponsors of terrorism list after the Sudanese government agreed to pay $335 million in compensation for families of American victims of terrorism.

The big picture: Trump's announcement is part of a wider agreement that is expected to include moves from Sudan toward normalizing relations with Israel.