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Welcome back. Please invite your friends and colleagues to join the conversation. Tell me anything on your mind, including what you think about what you are reading here and in the daily stream. Just reply to this email, or reach me at steve@axios.com.

And a special note for readers in Philly:

Future Shapers: A New Era in Cancer Care: Vice President and Dr. Biden, along with Sean Parker, are joining Axios' Mike Allen on Wednesday, November 8th, to discuss the future of cancer care and you're invited. Mike will also explore this topic with the Celgene CEO Mark Alles, cancer survivor and advocate Stefanie Joho, and Elizabeth Jaffee, the deputy director of the Kimmel Cancer Center at Johns Hopkins. The location is the National Constitution Center. RSVP here.

Now, let's start with ...