Dec 11, 2017

In early trial, new drug silences Huntington’s disease gene

An experimental drug could slow the spread of Huntington's disease, giving hopes to patients suffering from uncontrolled movements and mental confusion associated with the disease, reports The Guardian. An early-stage trial of the drug was conducted with 46 patients in the UK, Germany and Canada.

Why it matters: Huntington's disease is an inherited condition resulting from a genetic mutation. Current treatments can only help minimize the symptoms, instead of slowing it down.

Professor Sarah Tabriz at UK's University College of London said in a statement on Monday that the drug has lowered the level of the “toxic disease-causing protein in the nervous system, and the drug was safe and well-tolerated. The key now is to move quickly to a larger trial to test whether the drug slows disease progression.”

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Rebecca Falconer

In photos: Deadly Storm Dennis lashes U.K., Ireland and western France

A family is rescued from a property in Nantgarw, Wales, on Sunday. The storm comes a week after the U.K. was battered by storm Ciara, which killed two people, per the BBC. Photo: Matthew Horwood/Getty Images

Storm Dennis continued to pummel parts of England, Wales and Ireland over Sunday night with heavy rain after battering Northern Ireland and Scotland, per the official British weather agency the Met Office.

Why it matters: It's the second-strongest nontropical storm ever recorded in the North Atlantic Ocean, with its hurricane-force winds and heavy rains that caused widespread flooding across the U.K., the Washington Post notes. Police in Wales confirmed Sunday they found the body of a man who fell into a river as the storm lashed Ystradgynlais.

See photos53 mins ago - World

Axios

Sanders accuses Bloomberg of trying to "buy" the 2020 election

Sen. Bernie Sanders and Mike Bloomberg. Photos: Drew Angerer; Brett Carlsen/Getty Images

Sen. Bernie Sanders tore into 2020 rival Michael Bloomberg at a Las Vegas campaign event Saturday, saying the billionaire and former New York mayor is trying to "buy the presidency" by paying millions of dollars in advertising.

Why it matters: Bloomberg has surged in national polling recently, having poured millions of dollars into campaign ads largely targeting Trump. His candidacy has become an obvious foil for Sanders, whose grassroots campaign railing against billionaires and the establishment has vaulted him to front-runner status.

Go deeperUpdated 2 hours ago - Politics & Policy

Axios

Coronavirus cases rise, as more Americans on cruise confirmed ill

Data: The Center for Systems Science and Engineering at Johns Hopkins, the CDC, and China's NHC; Note: China refers to mainland China and the Diamond Princess is the cruise ship offshore Yokohama, Japan. Map: Danielle Alberti/Axios

A U.S. public health official confirms more than 40 Americans on the Diamond Princess cruise ship off Japan have coronavirus, while the remaining U.S. citizens without symptoms are being evacuated.

The big picture: COVID-19 has now killed at least 1,770 people and infected almost 70,000 others. Most cases and all but five of the deaths have occurred in mainland China. Taiwan confirmed its first death on Sunday, per multiple reports, in a 61-year-old man with underlying health conditions. Health officials were investigating how he became ill.

Go deeperUpdated 5 hours ago - Health