Photos: Greg Nash/Pool/AFP; Tom Williams/CQ-Roll Call, Inc via Getty Images

Sen. Lindsey Graham (R-S.C.) and Sen. Susan Collins (R-Maine) face rising odds in their high-profile re-election bids, according to a Quinnipiac poll released Wednesday.

Why it matters: Many thought Graham's Senate race was a long shot for Democrats, and the moderate Collins has served as a pivotal Republican swing vote on a number of key issues during the Trump presidency.

  • Collins, who has criticized Trump at times but voted to confirm Supreme Court Justice Brett Kavanaugh and to acquit the president in his impeachment trial, is down 54%-42% to her Democratic challenger Sara Gideon, Maine's House Speaker.
  • Graham is tied 48%-48% with Jaime Harrison, his Democratic challenger and the first African American chair of South Carolina's Democratic party.

Meanwhile: Democrat Amy McGrath, who has raised massive amounts of cash in her high-profile Kentucky Senate race, is down 53%-41% to Senate Majority Leader Mitch McConnell, according to the Quinnipiac poll.

What they're saying: "Senate control hangs in the balance as the GOP confronts a likely nail biter in South Carolina and a possible knockout in Maine, offset by a presumably solid lead in Kentucky," Quinnipiac analyst Tim Malloy said in a press release.

Methodology: 1,164 likely voters surveyed in Kentucky with an MOE of ±2.9 percentage points. 1,183 likely voters surveyed in Maine with an MOE of ±2.9 percentage points. 969 likely voters surveyed in South Carolina with an MOE of ±3.2 percentage points.

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Lindsey Graham says he will vote for Ginsburg's replacement before next election

Sen. Lindsey Graham. Photo: Tom Williams-Pool/Getty Images

Sen. Lindsey Graham (R-S.C.) on Saturday said he plans to support a vote on President Trump's nominee to fill the vacancy left by Supreme Court Justice Ruth Bader Ginsburg, who died on Friday, before the election.

Why it matters: Graham in 2016 opposed confirming President Obama's Supreme Court nominee, Merrick Garland, because it was an election year.

A court fight for the ages

The flag flies at half-staff as people mourn on the Supreme Court steps last night. Photo: Tasos Katopodis/Getty Images

Ruth Bader Ginsburg — feminist icon, legal giant, toast of pop culture — left this statement with granddaughter Clara Spera as cancer closed in: "My most fervent wish is that I will not be replaced until a new president is installed."

The big picture: For all that the nation owes "Notorious RBG" — the hip-hop-inspired nickname she enjoyed and embraced — Republicans are planning to do their best to be sure her robe is quickly filled, despite that last wish, with her ideological polar opposite.

Trump, McConnell to move fast to replace Ginsburg

Photo: Alex Wong/Getty Images

President Trump will move within days to nominate his third Supreme Court justice in just three-plus short years — and shape the court for literally decades to come, top Republican sources tell Axios.

Driving the news: Senate Majority Leader Mitch McConnell and Senate Republicans are ready to move to confirm Trump's nominee before Election Day, just 46 days away, setting up one of the most consequential periods of our lifetimes, the sources say.