Sign up for our daily briefing

Make your busy days simpler with the Axios AM and PM newsletters. Catch up on what's new and why it matters in just 5 minutes.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on the day's biggest business stories

Subscribe to the Axios Closer newsletter for insights into the day’s business news and trends and why they matter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios Pro Rata

Dive into the world of dealmakers across VC, PE and M&A with Axios Pro Rata. Delivered daily to your inbox by Dan Primack and Kia Kokalitcheva.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sports news worthy of your time

Binge on the stats and stories that drive the sports world with the Axios Sports newsletter. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Tech news worthy of your time

Get our smart take on technology from the Valley and D.C. with Axios Login. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Get the inside stories

Get an insider's guide to the new White House with Axios Sneak Peek. Sign up for free.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Catch up on coronavirus stories and special reports, curated by Mike Allen everyday

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Denver news?

Get a daily digest of the most important stories affecting your hometown with Axios Denver

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Des Moines news?

Get a daily digest of the most important stories affecting your hometown with the Axios Des Moines newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Twin Cities news?

Get a daily digest of the most important stories affecting your hometown with Axios Twin Cities

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Tampa Bay news?

Get a daily digest of the most important stories affecting your hometown with the Axios Tampa Bay newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Charlotte news?

Get a daily digest of the most important stories affecting your hometown with Axios Charlotte

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Nashville news?

Get a daily digest of the most important stories affecting your hometown with the Axios Nashville newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Columbus news?

Get a daily digest of the most important stories affecting your hometown with the Axios Columbus newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Dallas news?

Get a daily digest of the most important stories affecting your hometown with the Axios Dallas newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Austin news?

Get a daily digest of the most important stories affecting your hometown with the Axios Austin newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Atlanta news?

Get a daily digest of the most important stories affecting your hometown with the Axios Atlanta newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Philadelphia news?

Get a daily digest of the most important stories affecting your hometown with the Axios Philadelphia newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top Chicago news?

Get a daily digest of the most important stories affecting your hometown with the Axios Chicago newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Sign up for Axios NW Arkansas

Stay up-to-date on the most important and interesting stories affecting NW Arkansas, authored by local reporters

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Want a daily digest of the top DC news?

Get a daily digest of the most important stories affecting your hometown with the Axios DC newsletter.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!
Expand chart
Illustration: Rebecca Zisser/Axios

Scientists and ethicists are urging further debate on the current 14-day limit over research on human embryos.

Why it matters: Some scientists, speaking with Axios and others at an event hosted by Rice University's Baker Institute Wednesday, say expanded research on early embryo development would provide untapped insight into how humans, and their diseases, develop.

The science

Context: Embryo research is affected by an international agreement that limits embryo research to 14 days, which is when the embryo starts developing the primitive streak and its neural system.

  • Of note: The U.S. has adopted the international agreement as guidelines rather than as policy, as many other countries have done. However, alongside this agreement, various U.S. states have even stricter policies, with some like North Dakota banning all research.
  • Several speakers at the event said the 14-day limit was not really based on scientific thought but instead chosen in 1979 when In Vitro Fertilization (IVF) first started and people became worried about test tube babies. "None of it is actually scientific, I would argue," Rockefeller University's Ali Brivanlou said.
  • To be sure: At the time, the limit didn't matter since scientists didn't have the technological know-how to be able to develop embryo cells for that length of time.
  • However: Technology has advanced, and a couple years ago, Brivanlou's lab was able to develop embryos that successfully developed up to the 14-day mark and had to be frozen, a move he calls "one of the hardest things I've ever done."

What's happening now: Instead of human embryos, many researchers are using animal models such as mice, according to Kirstin R.W. Matthews, Baker Institute fellow in science and technology policy. The problem is while human and mice blastocysts look similar at 5 or 6 days, they look very different by day 14, she said.

  • Rice University's Daniel Wagner, who spoke at the event, also noted they've been able to pinpoint how some birth defects may originate in animal models, but "we can't really validate these detailed findings in humans."

Newest finding: Brivanlou's lab announced Wednesday in Nature they were able to confirm that humans have an "organizer structure" — a node they believe signals to newly-forming cells to differentiate into a skin cell or muscle cell, etc. Because organizers appear around the 14-day mark, they had not been confirmed in humans.

  • What they did: The team developed artificial human embryonic stem cells (hESCs), exposed them to two proteins to spur growth, and grafted them onto a chicken egg, creating what's called a chimera. There, the hESCs seemed to started directing nearby cells into what type of cells were needed, acting as the organizer.
  • The big question: During the first couple of days, the cells multiply quickly from 4 to 8 to 32 cells — "at what point does each of those cells know what they're going to be?" Brivanlou asks. "This is done through communication between cells." He says this applies to diseases as well, many of which start early. "Perhaps we could attack them as early as they start," Brivanlou said.
"It's pretty amazing. I spent a big chunk of my life on seeing how you make a tadpole from fertilized frog eggs," Brivanlou told Axios. "Now we're cracking the code of what it takes for making a human."
The ethics

There is a major disagreement about at what stage the human embryo can be considered a human being and where to draw the line with experimenting with chimeras.

  • These views range from the moment the egg is fertilized to the moment the fetus is viable outside the womb, according to Ana Iltis, director of Wake Forest University's Center for Bioethics, Health and Society, who spoke at the event.
  • Chimeras also tend to generate controversy. "For example, how many [human] cells do you put into it, and it is still a mouse?" Brivanlou said.

The discussion: The question remains on if the 14-day guidelines were to be altered, where the best point is to encourage research but respect the developing life form as well. Wagner pointed out that there are a multitude of avenues like institutional review boards that can host such discussions.

  • Brivanlou said 28 days may be a good mark, since it is after organs start to develop but before many are connected.
  • "If we were able to do more research, towards day 30 or so, we'd have a richer body of knowledge to go on," Matthews told Axios, adding that this topic presents difficult questions that need a national discussion, since a longer research period would need to be balanced by respect and care for the life created in the dish.
"There are good arguments for relaxing this time limit in order to study events such as [formulation of neural system] which are critical for development.  Moreover, this is a developmental stage at which many spontaneous abortions occur — we desperately need to find out more about this stage."
— Magdalena Zernicka-Goetz, developmental and stem cell biologist, University of Cambridge, told Axios

Go deeper: Watch the Baker Institute seminar here. Read these Axios stories on new advances in stem cell research, growing replacement human organs in sheep, and what's happening with fertility treatments. And, check out this piece in The Scientist on the first week of the embryo.

Go deeper

School principals are not OK

Principal Alice Hom (purple jacket) of New York's Yung Wing School P.S. 124 near a vaccination van in November. Photo: Michael Loccisano/Getty Images

The overwhelming majority of secondary school principals experienced frequent stress last school year, according to a RAND Corporation report out Wednesday.

The big picture: The stress levels among female principals and principals of color were especially stark, with nearly 40% in these groups reporting constant job-related stress, compared to about 24% of male principals and 26% of white principals.

It's official: Stock market having worst start to year ever

Data: FactSet; Chart: Axios Visuals

It's been a decidedly ugly start to the year for the stock market, with particular pain in the tech trade.

State of play: As of the end of trading Tuesday — the 16th session of the year — 2022 is now, officially, the worst-ever start in the history of the S&P 500, according to data from Ned Davis Research, a stock market research shop.

Surprising pandemic side effect: Soaring trade deficits

Source: Census Bureau and Bureau of Economic Analysis; Chart: Axios Visuals

Inflation and jobs may get all the economic headlines, but meanwhile a big shift is taking place in the underpinnings of the world economy: The U.S. trade deficit is soaring.

What's happening: Americans' spending on imported physical goods has gone through the roof, while exports are growing slowly, making the U.S. the world's consumer of last resort.

You’ve caught up. Now what?

Sign up for Mike Allen’s daily Axios AM and PM newsletters to get smarter, faster on the news that matters.

Please enter a valid email.

Please enter a valid email.

Subscription failed
Thank you for subscribing!